ReviewJournal of the International AIDS Society2013
Neurodevelopment in perinatally HIV-infected children: a concern for adolescence.
Review in Journal of the International AIDS Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed, 4 syntheses or guidelines pooled it, 184 citations in OpenAlex.
- School functioning of children with perinatal HIV-infection in high-income countries: A systematic review.PloS one · 2021Pooled it
- Interventions to Improve Antiretroviral Therapy Adherence Among Adolescents and Youth in Low- and Middle-Income Countries: A Systematic Review 2015-2019.AIDS and behavior · 2020Pooled it
- HIV-Associated Cognitive Impairment in Perinatally Infected Children: A Meta-analysis.Pediatrics · 2016Pooled it
- Audiological assessment of children with HIV/AIDS: a meta-analysis.Jornal de pediatriaPooled it
- The Value of a Motor Intervention for 3 to 6-Year-Old Children Infected with and Affected by HIV.International journal of environmental research and public health · 2022Trial
- Absence of neurocognitive disadvantage associated with paediatric HIV subtype A infection in children on antiretroviral therapy.Journal of the International AIDS Society · 2017Trial
- HIV-associated CD4+/CD8+ depletion in infancy is associated with neurometabolic reductions in the basal ganglia at age 5 years despite early antiretroviral therapy.AIDS (London, England) · 2016Trial
- Effect of Caregiver Training on the Neurodevelopment of HIV-Exposed Uninfected Children and Caregiver Mental Health: A Ugandan Cluster-Randomized Controlled Trial.Journal of developmental and behavioral pediatrics : JDBPTrial
- Tablet-Based Neurocognitive Tests for Ugandan Adolescents Living With HIV: Cross-Sectional Validation Study.JMIR mHealth and uHealth · 2026Article
- Effects of HIV and Adverse Childhood Experiences on Neurocognition.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Association of HIV infection and alcohol use on resting-state functional connectivity and mental health in youth living with perinatal HIV.Research square · 2026Article
- Epigenetic Age Acceleration, Neurocognition and Oral Health in Nigerian Adolescents With and Without HIV.The Pediatric infectious disease journal · 2026Article
- Executive Function and Adherence in Children and Adolescents Living With HIV: Evidence From the HIV-Associated Neurocognitive Disorders in Zambia (HANDZ) Study.Journal of child neurology · 2026Article
- Unmasking Bacillus Calmette-Guérin Immune Reconstitution Inflammatory Syndrome in a Perinatal HIV Transmission-A Case Report.Tropical medicine and infectious disease · 2025Article
- The Grenada Learning and Memory Scale: Psychometric features and normative data in Caribbean preschool children.Journal of the International Neuropsychological Society : JINS · 2024Article
- An interprofessional model of care for adolescents with perinatal HIV: A qualitative study.Health science reports · 2024Article
- Motivation levels and white matter microstructure in children living with HIV.Scientific reports · 2024Article
- Central auditory test performance predicts future neurocognitive function in children living with and without HIV.Scientific reports · 2024Article
- Central auditory test performance predicts future neurocognitive function in children living with and without HIV.Scientific reports · 2024Article
- Better Together: acceptability, feasibility and preliminary impact of chronic illness peer support groups for South African adolescents and young adults.Journal of the International AIDS Society · 2023Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Globally, an estimated 3.4 million children are living with HIV, yet little is known about the effects of HIV and antiretroviral treatment (ART) on the developing brain, and the neurodevelopmental and behavioural outcomes of perinatally HIV-infected (PHIV+) adolescents. We reviewed the literature on neurodevelopmental outcomes in PHIV+ children and adolescents, and summarized the current evidence on behaviour, general cognition, specific domains, hearing and language, school performance and physical disabilities due to neurological problems. Evidence suggests that PHIV+ children do not perform as well as controls on general cognitive tests, processing speed and visual-spatial tasks, and are at much higher risk for psychiatric and mental health problems. Children with AIDS-defining diagnoses are particularly at risk for poorer outcomes. A striking finding is the lack of published data specific to the adolescent age group (10-25 years), particularly from resource-constrained countries, which have the highest HIV prevalence. In addition, extreme heterogeneity in terms of timing and source of infection, and antiretroviral experience limits our ability to summarize findings of studies and generalize results to other settings. Due to the complex nature of the developing adolescent brain, environmental influences and variation in access to ART, there is an urgent need for research on the longitudinal trajectory of neurodevelopment among children and adolescents perinatally infected with HIV, especially in high burden resource-constrained settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.