ArticleMolecular plant pathology2013
A mutation in the expansin-like A2 gene enhances resistance to necrotrophic fungi and hypersensitivity to abiotic stress in Arabidopsis thaliana.
Article in Molecular plant pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
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70 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deciphering the molecular basis of abiotic stress response in cucumber (Cucumis sativus L.) using RNA-Seq meta-analysis, systems biology, and machine learning approaches.Scientific reports · 2023Pooled it
- Functional Analysis ofPlants (Basel, Switzerland) · 2026Article
- Genome-wide analysis of sunflower (Helianthus annuus) and Orobanche cumana reveals HaEXLA2 and HaEXLB2 as negative regulators of lignin-based resistance.Plant cell reports · 2026Article
- Review
- Molecular Breeding for Fungal Resistance in Common Bean.International journal of molecular sciences · 2025Review
- Analysis of Expansin genes in Cucurbitaceae and identification of candidate genes for stress resistance.Scientific reports · 2025Article
- Comparative Transcriptomic and Metabolomic Analysis of Two RelatedPhenomics (Cham, Switzerland) · 2025Article
- Silencing of disease susceptibility genes: an effective disease resistance strategy against fungal pathogens.Plant cell reports · 2025Review
- Polyploidy-mediated variations in glutamate receptor proteins linked to Fusarium wilt resistance in upland cotton.The Plant journal : for cell and molecular biology · 2025Article
- LncRNA81246 regulates resistance against tea leaf spot by interrupting the miR164d-mediated degradation of NAC1.The Plant journal : for cell and molecular biology · 2025Article
- Function diversity of the expansin subfamily genes inFrontiers in plant science · 2025Article
- Transcriptomic Profile of Tef (Plants (Basel, Switzerland) · 2024Article
- The Dynamic Interaction between Oil Palm andJournal of fungi (Basel, Switzerland) · 2024Article
- Comparative transcriptomic and phenotypic analysis of monoclonal and polyclonalFrontiers in plant science · 2024Article
- Transcriptome- and genome-wide systematic identification of expansin gene family and their expression in tuberous root development and stress responses in sweetpotato (Frontiers in plant science · 2024Article
- Genomic and transcriptomic analyses reveal polygenic architecture for ecologically important traits in aspen (Ecology and evolution · 2023Article
- Evolution and Expression of the Expansin Genes in Emmer Wheat.International journal of molecular sciences · 2023Article
- Investigation of the expansin gene family in sugar beet (Beta vulgaris) by the genome-wide level and their expression responses under abiotic stresses.Biologia futura · 2023Article
- A Switch from Latent to Typical Infection duringInternational journal of molecular sciences · 2023Article
- Genome engineering of disease susceptibility genes for enhancing resistance in plants.Functional & integrative genomics · 2023Review
10 more citing papers are in PubMed but not listed here.
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Expansins are cell wall loosening agents, known for their endogenous function in cell wall extensibility. The Arabidopsis expansin-like A2 (EXLA2) gene was identified by its down-regulation in response to infection by the necrotrophic pathogen Botrytis cinerea, and by the reduced susceptibility of an exla2 mutant to the same pathogen. The exla2 mutant was equally susceptible to Pseudomonas syringae pv. tomato, but was more resistant to the necrotrophic fungus Alternaria brassicicola, when compared with the wild-type or with transgenic, ectopic EXLA2-overexpressing lines. The exla2 mutants also enhanced tolerance to the phytoprostane-A1 . This suggests that the absence or down-regulation of EXLA2 leads to increased resistance to B. cinerea in a CORONATINE INSENSITIVE 1 (COI1)-dependent manner, and this down-regulation can be achieved by phytoprostane-A1 treatment. EXLA2 is induced significantly by salinity and cold, and by the exogenous application of abscisic acid. The exla2 mutant also showed hypersensitivity towards increased salt and cold, and this hypersensitivity required a functional abscisic acid pathway. The differential temporal expression of EXLA2 and the phenotypes in transgenic plants with altered expression of EXLA2 indicate that plant cell wall structure is an important player during Arabidopsis developmental stages. Our results indicate that EXLA2 appears to be important in response to various biotic and abiotic stresses, particularly in the pathogenesis of necrotrophic pathogens and in the tolerance to abiotic stress.
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