ArticleJournal of the peripheral nervous system : JPNS2013
Evaluation of dermal myelinated nerve fibers in diabetes mellitus.
Article in Journal of the peripheral nervous system : JPNS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Redefining distal symmetrical polyneuropathy features in type 1 diabetes: a systematic review.Acta diabetologica · 2022Pooled it
- Pacinian corpuscle loss on routine forefoot MRI as an imaging biomarker for large-fiber sensory dysfunction in type 2 diabetic polyneuropathy.European radiology · 2026Article
- Chitosan Protects Peripheral Nerves Against Damage Induced by Diabetes Mellitus.Life (Basel, Switzerland) · 2025Article
- MRI evaluation of Pacinian corpuscle number and distribution in the forefoot in diabetic sensorimotor polyneuropathy.Insights into imaging · 2025Article
- Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy.Brain : a journal of neurology · 2024Article
- Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy.Journal of clinical medicine · 2021Article
- Vibrotactile sense 5 years after carpal tunnel release in people with diabetes: A prospective study with matched controls.Diabetic medicine : a journal of the British Diabetic Association · 2021Observational
- Development of grading scales of pedal sensory loss using Mokken scale analysis on the Rotterdam Diabetic Foot Study Test Battery data.Muscle & nerve · 2019Article
- In-vivo reflectance confocal microscopy of Meissner's corpuscles in diabetic distal symmetric polyneuropathy.Journal of the neurological sciences · 2017Article
- The relationship of nerve fibre pathology to sensory function in entrapment neuropathy.Brain : a journal of neurology · 2014Article
- Cutaneous changes in diabetic patients: Primed for aberrant healing?Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Skin biopsies have primarily been used to study the non-myelinated nerve fibers of the epidermis in a variety of neuropathies. In this study, we have expanded the skin biopsy technique to glabrous, non-hairy skin to evaluate myelinated nerve fibers in the most highly prevalent peripheral nerve disease, diabetic polyneuropathy (DPN). Twenty patients with DPN (Type I, n = 9; Type II, n = 11) and 16 age-matched healthy controls (age 29-73) underwent skin biopsy of the index finger, nerve conduction studies (NCS), and composite neuropathy scoring. In patients with DPN, we found a statistically significant reduction of both mechanoreceptive Meissner corpuscles (MCs) and their afferent myelinated nerve fibers (p = 0.01). This myelinated nerve fiber loss was correlated with the decreased amplitudes of sensory/motor responses in NCS. This study supports the utilization of skin biopsy to quantitatively evaluate axonal loss of myelinated nerve fibers in patients with DPN.
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