ArticleMicrocirculation (New York, N.Y. : 1994)2013
Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm.
Article in Microcirculation (New York, N.Y. : 1994), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- In vitro vascularization improves in vivo functionality of human engineered cardiac tissues.Acta biomaterialia · 2026Article
- Hyperspectral wide-field-of-view imaging to study dynamic microcirculatory changes during hypoxia.American journal of physiology. Heart and circulatory physiology · 2022Article
- Article
- A simple automated method for continuous fieldwise measurement of microvascular hemodynamics.Microvascular research · 2019Article
- Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow.Nature reviews. Cancer · 2018Review
- Development of a mathematical model to estimate intra-tumor oxygen concentrations through multi-parametric imaging.Biomedical engineering online · 2016Article
- Design, evaluation, and application of engineered skeletal muscle.Methods (San Diego, Calif.) · 2016Review
- Snap-shot multispectral imaging of vascular dynamics in a mouse window-chamber model.Optics letters · 2015Article
- Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis.Radiation research · 2015Article
- Automated measurement of microcirculatory blood flow velocity in pulmonary metastases of rats.Journal of visualized experiments : JoVE · 2014Article
- In vivo spectral and fluorescence microscopy comparison of microvascular function after treatment with OXi4503, Sunitinib and their combination in Caki-2 tumors.Biomedical optics express · 2014Article
- Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease.Scientific reports · 2014Article
- Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer.PloS one · 2014Article
- Article
Corrections and comments
- Erratum issuedRajaram, Narasimhan [added]; Frees, Amy E [added]
Authors and funding
11 authors.
Funding
Abstract
objectiveHemodynamic properties of vascular beds are of great interest in a variety of clinical and laboratory settings. However, there presently exists no automated, accurate, technically simple method for generating blood velocity maps of complex microvessel networks.
methodsHere, we present a novel algorithm that addresses the problem of acquiring quantitative maps by applying pixel-by-pixel cross-correlation to video data. Temporal signals at every spatial coordinate are compared with signals at neighboring points, generating a series of correlation maps from which speed and direction are calculated. User-assisted definition of vessel geometries is not required, and sequential data are analyzed automatically, without user bias.
resultsVelocity measurements were validated against the dual-slit method and against in vitro capillary flow with known velocities. The algorithm was tested in three different biological models in order to demonstrate its versatility.
conclusionsThe hemodynamic maps presented here demonstrate an accurate, quantitative method of analyzing dynamic vascular systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.