ArticlePharmaceutical methods2011
The RP-HPLC method for simultaneous estimation of esomeprazole and naproxen in binary combination.
Article in Pharmaceutical methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Enantioselective recognition of esomeprazole with a molecularly imprinted sol-gel-based electrochemical sensor.Mikrochimica acta · 2022Article
- Fourth-order derivative spectrophotometric method for simultaneous determination of pseudoephedrine and naproxen in pharmaceutical dosage forms.Research in pharmaceutical sciencesArticle
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveA simple, precise, reliable, rapid, sensitive and validated RP-HPLC method has been developed to determine esomeprazole magnesium trihydrate (ESO) and naproxen (NAP) in synthetic mixture form. MATERIALS AND
methodsChromatographic separation achieved isocratically on Phenomenex, Luna C18 column (5 μm, 150mm × 4.60mm) and acetonitrile: phosphate buffer (pH 7.0) in the ratio of 50:50 (v/v) as the mobile phase, at a flow rate of 0.5 ml/min. Detection was carried out at 300 nm. The retention times for NAP and ESO was found to be 2.67 ±0.014 and 5.65 ±0.09 min respectively. Parameters such as linearity, precision, accuracy, recovery, specificity and ruggedness are studied as reported in the ICH guidelines.
resultsThe method was linear in the concentration range of 50-250 μg/ml for NAP and 2-10 μg/ml for ESO with correlation coefficient of 0.999 and 0.998 respectively. The mean recoveries obtained for NAP and ESO were 100.01% and 97.76 % respectively and RSD was less than 2. The correlation coefficients for all components are close to 1.
conclusionsDeveloped method was found to be accurate, precise, selective and rapid for simultaneous estimation of NAP and ESO.
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