ArticleEvidence-based complementary and alternative medicine : eCAM2013
Propolis Modifies Collagen Types I and III Accumulation in the Matrix of Burnt Tissue.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Applications of Propolis in Dentistry: A Review.Ethiopian journal of health sciences · 2018Pooled it
- Electrospun PLGA-Propolis Scaffolds Regulate Collagen Architecture in Burn Wounds.International journal of molecular sciences · 2026Article
- Influence of Propolis-Containing Nonwoven PLGA Dressings on Dermatan and Chondroitin Sulfate Dynamics During Burn-Wound Healing.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The Effect of Topical Propolis Ointment on Severity of Episiotomy Pain and Wound Healing: A Triple-Blinded Randomized Controlled Clinical Trial.Journal of caring sciences · 2025Article
- Propolis Stands out as a Multifaceted Natural Product: Meta-Analysis on Its Sources, Bioactivities, Applications, and Future Perspectives.Life (Basel, Switzerland) · 2025Review
- A Comprehensive Analysis of Liposomal-Based Nanocarriers for Treating Skin and Soft Tissue Infection.Current drug delivery · 2025Review
- A Path to the Formation Mechanism of Propolis Nanoparticles, their Cytotoxicity on 3T3 Fibroblasts, Metastatic Murine B16F10 Cells, and theirAnti-cancer agents in medicinal chemistry · 2025Article
- Randomized Clinical Evaluation of the Healing Activity of Green Propolis Ointment in Individuals with Lower Limb Ulcers Resulting from Leprosy: Preliminary Results of a Pilot Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Advances in arthropod-inspired bionic materials for wound healing.Materials today. Bio · 2024Review
- Hive Products: Composition, Pharmacological Properties, and Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Applications of honeybee-derived products in bone tissue engineering.Bone reports · 2024Review
- Development of propolis, hyaluronic acid, and vitamin K nano-emulsion for the treatment of second-degree burns in albino rats.BMC complementary medicine and therapies · 2024Article
- Applications of propolis-based materials in wound healing.Archives of dermatological research · 2023Review
- Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis.International journal of molecular sciences · 2023Article
- Preparation and evaluation of a polycaprolactone/chitosan/propolis fibrous nanocomposite scaffold as a tissue engineering skin substitute.BioImpacts : BI · 2023Article
- Histological, Immunohistochemical and Antioxidant Analysis of Skin Wound Healing Influenced by the Topical Application of Brazilian Red Propolis.Antioxidants (Basel, Switzerland) · 2022Article
- Chemical Variability and Pharmacological Potential of Propolis as a Source for the Development of New Pharmaceutical Products.Molecules (Basel, Switzerland) · 2022Review
- Narrative review of the mechanism of natural products and scar formation in wound repair.Annals of translational medicine · 2022Review
- Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Formulation and characterization of propolis and tea tree oil nanoemulsion loaded with clindamycin hydrochloride for wound healing:Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing represents an interactive process which requires highly organized activity of various cells, synthesizing cytokines, growth factors, and collagen. Collagen types I and III, serving as structural and regulatory molecules, play pivotal roles during wound healing. The aim of this study was to compare the propolis and silver sulfadiazine therapeutic efficacy throughout the quantitative and qualitative assessment of collagen types I and III accumulation in the matrix of burnt tissues. Burn wounds were inflicted on pigs, chosen for the evaluation of wound repair because of many similarities between pig and human skin. Isolated collagen types I and III were estimated by the surface plasmon resonance method with a subsequent collagenous quantification using electrophoretic and densitometric analyses. Propolis burn treatment led to enhanced collagens and its components expression, especially during the initial stage of the study. Less expressed changes were observed after silver sulfadiazine (AgSD) application. AgSD and, with a smaller intensity, propolis stimulated accumulation of collagenous degradation products. The assessed propolis therapeutic efficacy, throughout quantitatively and qualitatively analyses of collagen types I and III expression and degradation in wounds matrix, may indicate that apitherapeutic agent can generate favorable biochemical environment supporting reepithelization.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.