ReviewClinical & developmental immunology2013
The link between ankylosing spondylitis, Crohn's disease, Klebsiella, and starch consumption.
Review in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
- Causal Inference and Shared Molecular Pathways in Crohn's Disease, Celiac Disease, and Ankylosing Spondylitis: Integrative Mendelian Randomization and Transcriptomic Analysis.International journal of molecular sciences · 2025Article
- Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases.Journal of translational autoimmunity · 2025Review
- The Role of Diet in Modulating Inflammation and Oxidative Stress in Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis.Nutrients · 2025Review
- Genetic Risk of Ankylosing Spondylitis and Second-Line Therapy Need in Crohn's Disease: A Mendelian Randomization Study.Journal of clinical medicine · 2024Article
- Polymorphic variation of the DEFB1 gene might contribute to the development of ankylosing spondylitis: a preliminary study.Molecular biology reports · 2024Article
- Sterilizing orthodontic appliances: A systematic review and meta-analysis on the available methods.Journal of orthodontic science · 2023Review
- Evaluation of Antioxidant Capacity and Gut Microbiota Modulatory Effects of Different Kinds of Berries.Antioxidants (Basel, Switzerland) · 2022Article
- Risk of nonpulmonary infections requiring hospitalization in spondyloarthritis.Immunity, inflammation and disease · 2022Article
- Nicotine Increases Macrophage Survival through α7nAChR/NF-κB Pathway inMicroorganisms · 2021Article
- Microbial-derived antigens and metabolites in spondyloarthritis.Seminars in immunopathology · 2021Review
- Nicotine Modulates MyD88-Dependent Signaling Pathway in Macrophages during Mycobacterial Infection.Microorganisms · 2020Article
- Mystery Solved: Why Smoke Extract Worsens Disease in Smokers with Crohn's Disease and Not Ulcerative Colitis? Gut MAP!Microorganisms · 2020Article
- Draft Genomic Sequence of Multidrug-Resistant Klebsiella pneumoniae B8S35, Isolated from Retail Chicken Skin.Microbiology resource announcements · 2019Article
- In vitro evaluation of microbial contamination and the disinfecting efficacy of chlorhexidine on orthodontic brackets.Progress in orthodontics · 2019Article
- Usefulness of complex bacteriological and serological analysis in patients with spondyloarthritis.Experimental and therapeutic medicine · 2019Article
- Rifaximin Alters Intestinal Microbiota and Prevents Progression of Ankylosing Spondylitis in Mice.Frontiers in cellular and infection microbiology · 2019Article
- SmallFrontiers in microbiology · 2019Article
- Remission of aggressive autoimmune disease (dermatomyositis) with removal of infective jaw pathology and ozone therapy: review and case report.Auto- immunity highlights · 2018Article
- Microbiota Composition May Predict Anti-Tnf Alpha Response in Spondyloarthritis Patients: an Exploratory Study.Scientific reports · 2018Observational
- Relationship between diet and ankylosing spondylitis: A systematic review.European journal of rheumatology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both ankylosing spondylitis (AS) and Crohn's disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen, Klebsiella pneumoniae, is the most likely triggering factor involved in the initiation and development of these diseases. Increased starch consumptions by genetically susceptible individuals such as those possessing HLA-B27 allelotypes could trigger the disease in both AS and CD by enhancing the growth and perpetuation of the Klebsiella microbes in the bowel. Exposure to increased levels of these microbes will lead to the production of elevated levels of anti-Klebsiella antibodies as well as autoantibodies against cross-reactive self-antigens with resultant pathological lesions in the bowel and joints. Hence, a decrease of starch-containing products in the daily dietary intake could have a beneficial therapeutic effect on the disease especially when used in conjunction with the currently available medical therapies in the treatment of patients with AS and CD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.