Evidence map›Paper›PMID 23781198›Full record

ArticleFrontiers in neuroinformatics2013

The Virtual Brain: a simulator of primate brain network dynamics.

Paula Sanz Leon, Stuart A Knock, M Marmaduke Woodman, Lia Domide, Jochen Mersmann, Anthony R McIntosh, Viktor Jirsa

Abstract read
In one paragraph

Article in Frontiers in neuroinformatics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 257 papers.

0numbers the graph read from it
0cells of the map it votes in
257citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

257 citing papers in PubMed.

  1. Drug repurposing in hereditary ataxia.npj drug discovery · 2026
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  4. The Cerebellar Connectome.Cerebellum (London, England) · 2026
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  19. Biophysical mechanisms of default mode network function and dysfunction.bioRxiv : the preprint server for biology · 2026
    Article
  20. An Interactive Brain Atlas of Knowledge.bioRxiv : the preprint server for biology · 2026
    Article

197 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paula Sanz LeonInstitut de Neurosciences des Systèmes, Aix Marseille Université Marseille, France.
Stuart A Knock
M Marmaduke Woodman
Lia Domide
Jochen Mersmann
Anthony R McIntosh
Viktor Jirsa

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present The Virtual Brain (TVB), a neuroinformatics platform for full brain network simulations using biologically realistic connectivity. This simulation environment enables the model-based inference of neurophysiological mechanisms across different brain scales that underlie the generation of macroscopic neuroimaging signals including functional MRI (fMRI), EEG and MEG. Researchers from different backgrounds can benefit from an integrative software platform including a supporting framework for data management (generation, organization, storage, integration and sharing) and a simulation core written in Python. TVB allows the reproduction and evaluation of personalized configurations of the brain by using individual subject data. This personalization facilitates an exploration of the consequences of pathological changes in the system, permitting to investigate potential ways to counteract such unfavorable processes. The architecture of TVB supports interaction with MATLAB packages, for example, the well known Brain Connectivity Toolbox. TVB can be used in a client-server configuration, such that it can be remotely accessed through the Internet thanks to its web-based HTML5, JS, and WebGL graphical user interface. TVB is also accessible as a standalone cross-platform Python library and application, and users can interact with the scientific core through the scripting interface IDLE, enabling easy modeling, development and debugging of the scientific kernel. This second interface makes TVB extensible by combining it with other libraries and modules developed by the Python scientific community. In this article, we describe the theoretical background and foundations that led to the development of TVB, the architecture and features of its major software components as well as potential neuroscience applications.

Indexed as

connectomefull-brain network modellarge-scale simulationneural massespythontime delaysvirtual brainweb platform

Identifiers

PMID23781198
PMCPMC3678125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.