ArticleProceedings of the National Academy of Sciences of the United States of America2013
Helical flow of surface protein required for bacterial gliding motility.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 151 citations in OpenAlex.
- Distinct motors, shared mechanics: unifying principles of microbial gliding.Journal of bacteriology · 2026Review
- Chiral gliding: Right-handed navigation of filamentous cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bacterial motility in rhizosphere colonization: mechanisms, constraints, and implications for microbial inoculants.The ISME journal · 2026Review
- Complex compositional and metabolic response of river sediment microbiomes to multiple anthropogenic stressors.ISME communications · 2026Article
- Pleiotropic effects of signal peptide peptidase A (Frontiers in veterinary science · 2026Article
- A shared mechanism for Bacteroidota protein transport and gliding motility.Nature communications · 2025Article
- Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae.Communications biology · 2025Article
- Description of high-altitude, cold-adaptive, metabolically versatileMicrobiology spectrum · 2025Article
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- Effects of curvature on growing films of microorganisms.Biophysical journal · 2025Article
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- Methylation of foreign DNA overcomes the restriction barrier ofApplied and environmental microbiology · 2025Article
- Swarming bacteria exhibit developmental phase transitions to establish scattered colonies in new regions.The ISME journal · 2025Article
- Identification of nanaomycin A and its analogs by a newly established screening method for functional inhibitors of the type IX secretion system in Porphyromonas gingivalis.The Journal of antibiotics · 2025Article
- Visualization of peptidoglycan layer isolated from gliding diderm bacteria,Biophysics and physicobiology · 2025Article
- Gliding direction ofBiophysics and physicobiology · 2025Article
- A geometrical theory of gliding motility based on cell shape and surface flow.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gliding motility proteins GldJ and SprB contribute toJournal of bacteriology · 2024Article
- Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon.Nature microbiology · 2024Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells of Flavobacterium johnsoniae and of many other members of the phylum Bacteroidetes exhibit rapid gliding motility over surfaces by a unique mechanism. These cells do not have flagella or pili; instead, they rely on a novel motility apparatus composed of Gld and Spr proteins. SprB, a 669-kDa cell-surface adhesin, is required for efficient gliding. SprB was visualized by electron microscopy as thin 150-nm-long filaments extending from the cell surface. Fluorescence microscopy revealed movement of SprB proteins toward the poles of the cell at ∼2 μm/s. The fluorescent signals appeared to migrate around the pole and continue at the same speed toward the opposite pole along an apparent left-handed helical closed loop. Movement of SprB, and of cells, was rapidly and reversibly blocked by the addition of carbonyl cyanide m-chlorophenylhydrazone, which dissipates the proton gradient across the cytoplasmic membrane. In a gliding cell, some of the SprB protein appeared to attach to the substratum. The cell body moved forward and rotated with respect to this point of attachment. Upon reaching the rear of the cell, the attached SprB often was released from the substratum, and apparently recirculated to the front of the cell along a helical path. The results suggest a model for Flavobacterium gliding, supported by mathematical analysis, in which adhesins such as SprB are propelled along a closed helical loop track, generating rotation and translation of the cell body.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.