Evidence map›Paper›PMID 23781068›Full record

ArticlemBio2013

Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections.

Le Van Tan, H Rogier van Doorn, Ho Dang Trung Nghia, Tran Thi Hong Chau, Le Thi Phuong Tu, Michel de Vries, Marta Canuti, Martin Deijs, Maarten F Jebbink, Stephen Baker and 15 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 126 citations in OpenAlex.

  1. Article
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  5. Animals : an open access journal from MDPI · 2024
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 3 countries.

Le Van TanOxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, South East Asia Infectious Diseases Clinical Research Network, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. tanlv@oucru.org
H Rogier van Doorn
Ho Dang Trung Nghia
Tran Thi Hong Chau
Le Thi Phuong Tu
Michel de Vries
Marta Canuti
Martin Deijs
Maarten F Jebbink
Stephen Baker
Juliet E Bryant
Nguyen Thi Tham
Nguyen Thi Thuy Chinh BKrong
Maciej F Boni
Tran Quoc Loi
Le Thi Phuong
Joost T P Verhoeven
Martin Crusat
Rienk E Jeeninga
Constance Schultsz
Nguyen Van Vinh Chau
Tran Tinh Hien
Lia van der Hoek
Jeremy Farrar
Menno D de Jong
Oxford University Clinical Research Unit · VNHospital for Tropical Diseases · VNUniversity of Amsterdam · NLAcademic Medical Center · NLDong Thap Hospital · VNHospital for Tropical Diseases · GBUniversity of Oxford · GB

Funding

Wellcome Trust 089276Wellcome Trust 089276/Z/09/ZWellcome Trust 093724Wellcome Trust 093724/Z/10/ZWellcome Trust 100087
6 · The paper itself

Abstract

Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus.

Indexed as

AdolescentAdultAgedAnimalsCentral Nervous System InfectionsChildChild, PreschoolCircoviridaeCircoviridae InfectionsCluster AnalysisDNA, ViralFemaleGenome, ViralHumansInfantMaleDNA, Viral

Identifiers

PMID23781068
PMCPMC3684831
OpenAlexW2154953108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.