ArticleJournal of cell science2013
A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Irisin, a link among fatty liver disease, physical inactivity and insulin resistance.International journal of molecular sciences · 2014Pooled it
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- Age-dependent progenitor switching shapes adult brown adipose tissue heterogeneity.Research square · 2026Article
- Exosome miR-152-3p derived from small intestinal epithelium modulates aging process in adipocytes.3 Biotech · 2025Article
- Thermogenic Fat as a New Obesity Management Tool: From Pharmaceutical Reagents to Cell Therapies.Biomedicines · 2024Review
- A single-cell sequence analysis of mouse subcutaneous white adipose tissue reveals dynamic changes during weaning.Communications biology · 2024Article
- Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors.PLoS biology · 2023Article
- The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia.Reproductive biology and endocrinology : RB&E · 2022Article
- The Adipose Tissue Macrophages Central to Adaptive Thermoregulation.Frontiers in immunology · 2022Review
- The cellular and functional complexity of thermogenic fat.Nature reviews. Molecular cell biology · 2021Review
- Expression of a membrane-targeted fluorescent reporter disrupts auditory hair cell mechanoelectrical transduction and causes profound deafness.Hearing research · 2021Article
- GADD45α drives brown adipose tissue formation through upregulating PPARγ in mice.Cell death & disease · 2020Article
- Elucidating the Regulatory Role of Melatonin in Brown, White, and Beige Adipocytes.Advances in nutrition (Bethesda, Md.) · 2020Review
- Brown adipocytes from induced pluripotent stem cells-how far have we come?Annals of the New York Academy of Sciences · 2020Review
- The Beige Adipocyte as a Therapy for Metabolic Diseases.International journal of molecular sciences · 2019Review
- Brown Adipose Tissue Development and Metabolism.Handbook of experimental pharmacology · 2019Review
- The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF.Scientific reports · 2018Article
- Adapting to obesity with adipose tissue inflammation.Nature reviews. Endocrinology · 2017Review
- Metabolic activity of brown, "beige," and white adipose tissues in response to chronic adrenergic stimulation in male mice.American journal of physiology. Endocrinology and metabolism · 2016Article
- BMP-9 enhances fibroblast growth factor 21 expression and suppresses obesity.Biochimica et biophysica acta · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A worldwide epidemic of obesity and its associated metabolic disorders raise the significance of adipocytes, their origins and characteristics. Our previous study has demonstrated that interscapular brown adipose tissue (BAT), but not intramuscular adipose, is derived from the Pax3-expressing cell lineage. Here, we show that various depots of subcutaneous (SAT) and visceral adipose tissue (VAT) are highly heterogeneous in the Pax3 lineage origin. Interestingly, the relative abundance of Pax3 lineage cells in SAT depots is inversely correlated to expression of BAT signature genes including Prdm16, Pgc1a (Ppargc1a) and Ucp1. FACS analysis further demonstrates that adipocytes differentiated from non-Pax3 lineage preadipocytes express higher levels of BAT and beige adipocyte signature genes compared with the Pax3 lineage adipocytes within the same depots. Although both Pax3 and non-Pax3 lineage preadipocytes can give rise to beige adipocytes, the latter contributes more significantly. Consistently, genetic ablation of Pax3 lineage cells in SAT leads to increased expression of beige cell markers. Finally, non-Pax3 lineage beige adipocytes are more responsive to cAMP-agonist-induced Ucp1 expression. Taken together, these results demonstrate widespread heterogeneity in Pax3 lineage origin, and its inverse association with BAT gene expression within and among subcutaneous adipose depots.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.