ArticleDiabetes care2013
Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Global prevalence of erectile dysfunction and its associated risk factors among men with type 1 diabetes: a systematic review and meta-analysis.International journal of impotence research · 2024Pooled it
- The Association of Erectile Dysfunction and Cardiovascular Disease: A Systematic Critical Review.American journal of men's health · 2017Pooled it
- Erectile dysfunction, type 2 diabetes, and cardiovascular disease: a narrative review and insights from a global real-world cohort analysis.Frontiers in clinical diabetes and healthcare · 2026Review
- [Erectile dysfunction-It is time to act! : Practical tips and current guideline recommendations for diagnostics and treatment of a still underestimated disease].Urologie (Heidelberg, Germany) · 2026Article
- Quality of Chatbot Responses to the Most Popular Questions Regarding Erectile Dysfunction.Urology research & practice · 2025Article
- Article
- Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunction.Scientific reports · 2023Article
- The flow index provides a comprehensive assessment of erectile dysfunction by combining blood flow velocity and vascular diameter.Scientific reports · 2022Article
- Prevalence of erectile dysfunction in Type 2 diabetes mellitus (T2DM) and its predictors among diabetic men.Journal of family medicine and primary care · 2022Article
- Psychosexual Health and Sexual Medicine in Consultation-Liaison Psychiatry.Indian journal of psychiatry · 2022Article
- Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs.Nature reviews. Cardiology · 2022Review
- Sexual dysfunctions and short-term glucose variability in young men with type 1 diabetes.Hormones (Athens, Greece) · 2021Article
- Discoveries from the study of longstanding type 1 diabetes.Diabetologia · 2021Review
- Proteomic analysis of oxidative stress response in human umbilical vein endothelial cells (HUVECs): role of heme oxygenase 1 (HMOX1) in hypoxanthine-induced oxidative stress in HUVECs.Translational andrology and urology · 2020Article
- Circulating endothelial progenitor cells in type 1 diabetic patients with erectile dysfunction.Endocrine · 2015Article
- Diabetes and sexual dysfunction: current perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Review
- Type 1 diabetes and cardiovascular disease.Cardiovascular diabetology · 2013Review
- Lifestyle modifications and erectile dysfunction: what can be expected?Asian journal of andrologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveVascular dysfunction is a major contributor to diabetes complications. It is also the primary physiologic cause of erectile dysfunction and considered an independent predictor of cardiovascular disease (CVD) in males over age 40 years. A cohort of individuals with 50 or more years of type 1 diabetes, Joslin Medalists, have low rates of small but not large vessel complications. This study aims to identify the prevalence and longitudinal association of sexual dysfunction (SD) with CVD in Joslin Medalists. RESEARCH DESIGN AND
methodsDescription and association of self-assessment of SD in males of the Medalist cohort by self-reported sexual problems with CVD. SD is validated through the use of the abbreviated International Index of Erectile Dysfunction (IIEF).
resultsOf 301 males in the Medalist Study, 69.8% reported a history of SD. Unadjusted risk factors included elevated glycated hemoglobin (HbA1c) (P=0.02), elevated BMI (P=0.03), higher total cholesterol (P=0.02), lower HDL (P<0.01), and increased levels of interleukin-6 (P=0.03). SD was independently associated with CVD (age-, HbA1c-, and BMI-adjusted OR 1.9 [95% CI 1.0-3.5]). In adjusted analyses, retinal, neural, and renal complications were not associated (P>0.05) with SD. Current report of SD (IIEF score≤17) in a subset of Medalists was significantly correlated with self-reported longitudinal SD.
conclusionsSD in those with extreme-duration type 1 diabetes is independently associated with CVD, representing a large-vessel pattern. The findings suggest that SD may predict CVD in those with type 1 diabetes of long duration. These individuals have also been found to be relatively free of microvascular complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.