Evidence map›Paper›PMID 23780708›Full record

ArticleProteomics2013

Proteomic profiling of the mitochondrial inner membrane of rat renal proximal convoluted tubules.

Dana M Freund, Jessica E Prenni, Norman P Curthoys

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dana M FreundDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA.
Jessica E Prenni
Norman P Curthoys
Colorado State University · US

Funding

CONTROL OF RENAL GLUTAMINASE INDUCTION DURING ACIDOSISR01DK037124 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CURTHOYS, NORMAN P. · 1987 to 2012
$2.7M
Proteomic Analysis of Renal Response to AcidosisR21DK075517 · NIDDK · COLORADO STATE UNIVERSITY · PI CURTHOYS, NORMAN P. · 2007 to 2008
$389k
NIDDK NIH HHS DK-37124NIDDK NIH HHS DK-75517NIDDK NIH HHS R01 DK037124NIDDK NIH HHS R21 DK075517
6 · The paper itself

Abstract

The proximal convoluted tubule is the primary site of renal fluid, electrolyte, and nutrient reabsorption, processes that consume large amounts of adenosine-5'-triphosphate. Previous proteomic studies have profiled the adaptions that occur in this segment of the nephron in response to the onset of metabolic acidosis. To extend this analysis, a proteomic workflow was developed to characterize the proteome of the mitochondrial inner membrane of the rat renal proximal convoluted tubule. Separation by LC coupled with analysis by MS/MS (LC-MS/MS) confidently identified 206 proteins in the combined samples. Further proteomic analysis identified 14 peptides that contain an N-ɛ-acetyl-lysine, seven of which are novel sites. This study provides the first proteomic profile of the mitochondrial inner membrane proteome of this segment of the rat renal nephron. The MS data have been deposited in the ProteomeXchange with the identifier PXD000121.

Indexed as

AnimalsChromatography, LiquidKidney Tubules, ProximalLysineMitochondrial MembranesMitochondrial ProteinsProteomeProteomicsRatsTandem Mass SpectrometryLysineMitochondrial ProteinsN-epsilon-acetyllysineProteomeAnimal proteomicsLysine acetylationMitochondrial inner membraneProximal convoluted tubule

Identifiers

PMID23780708
PMCPMC3826448
OpenAlexW2048506576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.