ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2013
Region-specific epithelial cell dynamics during branching morphogenesis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner.Developmental cell · 2024Article
- Tissue Morphogenesis Through Dynamic Cell and Matrix Interactions.Annual review of cell and developmental biology · 2023Review
- Submandibular gland epithelial development and the importance of junctions.Tissue barriers · 2023Review
- Configurational entropy is an intrinsic driver of tissue structural heterogeneity.bioRxiv : the preprint server for biology · 2023Article
- Constriction imposed by basement membrane regulates developmental cell migration.PLoS biology · 2023Article
- Article
- Specification of the patterning of a ductal tree during branching morphogenesis of the submandibular gland.Scientific reports · 2021Article
- Mechanisms of 3D cell migration.Nature reviews. Molecular cell biology · 2019Review
- Branching pattern and morphogenesis of medusa tentacles in the jellyfishZoological letters · 2019Article
- Basement Membranes in Development and Disease.Current topics in developmental biology · 2018Review
- Generating tissue topology through remodeling of cell-cell adhesions.Experimental cell research · 2017Review
- RETRACTED: Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesisDevelopment (Cambridge, England) · 2017Article
- Patterned cell and matrix dynamics in branching morphogenesis.The Journal of cell biology · 2017Review
- Encapsulation of primary salivary gland cells in enzymatically degradable poly(ethylene glycol) hydrogels promotes acinar cell characteristics.Acta biomaterialia · 2017Article
- Biomaterials-based strategies for salivary gland tissue regeneration.Biomaterials science · 2016Article
- Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration.Development (Cambridge, England) · 2016Article
- ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis.Cell reports · 2016Article
- The contribution of specific cell subpopulations to submandibular salivary gland branching morphogenesis.Current opinion in genetics & development · 2015Review
- Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications.Tissue engineering. Part A · 2015Article
- Heterotypic control of basement membrane dynamics during branching morphogenesis.Developmental biology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEpithelial cells of developing embryonic organs, such as salivary glands, can display substantial motility during branching morphogenesis. Their dynamic movements and molecules involved in their migration are not fully characterized.
resultsWe generated transgenic mice expressing photo-convertible KikGR and tracked the movements of individual cells highlighted by red fluorescence in different regions of developing salivary glands. Motility was highest for outer bud epithelial cells adjacent to the basement membrane, lower in inner bud cells, and lowest in duct cells. The highly motile outer cells contacting the basement membrane were pleomorphic, whereas inner cells were rounded. Peripheral cell motility was disrupted by antibodies inhibiting α6+β1 integrins and the nonmuscle myosin II inhibitor blebbistatin. Inner bud cell migration was unaffected by these inhibitors, but their rate of migration was stimulated by inhibiting E-cadherin.
conclusionsCell motility in developing salivary glands was highest in cells in contact with the basement membrane. The basement membrane-associated motility of these outer bud cells depended on integrins and myosin II, but not E-cadherin. In contrast, motility of inner bud cells was restrained by E-cadherin. These findings identify the importance of integrin-dependent basement membrane association for the morphology, tissue organization, and lateral motility of morphogenetic epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.