ArticleThe Journal of membrane biology2013
On the electroporation thresholds of lipid bilayers: molecular dynamics simulation investigations.
Article in The Journal of membrane biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Bidirectional Modulation on Electroporation Induced by Membrane Tension Under the Electric Field.ACS omega · 2024Article
- Effects of Normal and Lateral Electric Fields on Membrane Mechanical Properties.The journal of physical chemistry. B · 2024Article
- All-atom molecular dynamics simulations of the combined effects of different phospholipids and cholesterol content on electroporation.RSC advances · 2022Article
- Identification of electroporation sites in the complex lipid organization of the plasma membrane.eLife · 2022Article
- Mechanical properties of ester- and ether-DPhPC bilayers: A molecular dynamics study.Journal of the mechanical behavior of biomedical materials · 2021Article
- EView: An electric field visualization web platform for electroporation-based therapies.Computer methods and programs in biomedicine · 2020Article
- The Voltage-Dependent Deactivation of the KvAP Channel Involves the Breakage of Its S4 Helix.Frontiers in molecular biosciences · 2020Article
- Molecular dynamics simulation of reversible electroporation with Martini force field.Biomedical engineering online · 2019Article
- Calcium electroporation and electrochemotherapy for cancer treatment: Importance of cell membrane composition investigated by lipidomics, calorimetry and in vitro efficacy.Scientific reports · 2019Article
- Membrane potential and dynamics in a ternary lipid mixture: insights from molecular dynamics simulations.Physical chemistry chemical physics : PCCP · 2018Article
- Electropore Formation in Mechanically Constrained Phospholipid Bilayers.The Journal of membrane biology · 2018Article
- The role of gel-phase domains in electroporation of vesicles.Scientific reports · 2018Article
- Functional Annotation of Ion Channel Structures by Molecular Simulation.Structure (London, England : 1993) · 2016Article
- Education on electrical phenomena involved in electroporation-based therapies and treatments: a blended learning approach.Biomedical engineering online · 2016Article
- The Effect of Tethers on Artificial Cell Membranes: A Coarse-Grained Molecular Dynamics Study.PloS one · 2016Article
- Energy-efficient biomass processing with pulsed electric fields for bioeconomy and sustainable development.Biotechnology for biofuels · 2016Review
- Electroporation-mediated gene delivery.Advances in genetics · 2015Article
- Electroporation in food processing and biorefinery.The Journal of membrane biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electroporation relates to the cascade of events that follows the application of high electric fields and that leads to cell membrane permeabilization. Despite a wide range of applications, little is known about the electroporation threshold, which varies with membrane lipid composition. Here, using molecular dynamics simulations, we studied the response of dipalmitoyl-phosphatidylcholine, diphytanoyl-phosphocholine-ester and diphytanoyl-phosphocholine-ether lipid bilayers to an applied electric field. Comparing between lipids with acyl chains and methyl branched chains and between lipids with ether and ester linkages, which change drastically the membrane dipole potential, we found that in both cases the electroporation threshold differed substantially. We show, for the first time, that the electroporation threshold of a lipid bilayer depends not only on the "electrical" properties of the membrane, i.e., its dipole potential, but also on the properties of its component hydrophobic tails.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.