ArticleCancer prevention research (Philadelphia, Pa.)2013
Chronic social isolation is associated with metabolic gene expression changes specific to mammary adipose tissue.
Article in Cancer prevention research (Philadelphia, Pa.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chronic psychosocial stress: a role in breast cancer etiology?Frontiers in oncology · 2026Pooled it
- Global Trends and Research Hotspots in Social Isolation Among Cancer Patients: A Bibliometric Analysis (2005-2024).Journal of multidisciplinary healthcare · 2025Review
- Psychosocial stressors and breast cancer gene expression in the Black Women's Health Study.Breast cancer research and treatment · 2024Article
- Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus.BMC genomics · 2023Article
- Differential effects of acute versus chronic dietary fructose consumption on metabolic responses in FVB/N mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Impact of neighborhood socioeconomic status, income segregation, and greenness on blood biomarkers of inflammation.Environment international · 2022Article
- Stress sensing within the breast tumor microenvironment: how glucocorticoid receptors live in the moment.Essays in biochemistry · 2021Review
- Tissue-Specific Warburg Effect in Breast Cancer and Cancer-Associated Adipose Tissue-Relationship between AMPK and Glycolysis.Cancers · 2021Article
- An overview of cancer health disparities: new approaches and insights and why they matter.Carcinogenesis · 2021Review
- Chronic Isolation Stress Affects Central Neuroendocrine Signaling Leading to a Metabolically Active Microenvironment in a Mouse Model of Breast Cancer.Frontiers in behavioral neuroscience · 2021Article
- Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal.Scientific reports · 2020Article
- COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options.Cardiovascular research · 2020Article
- Long-Term Impact of Social Isolation and Molecular Underpinnings.Frontiers in genetics · 2020Review
- Implication of Spiritual Network Support System in Epigenomic Modulation and Health Trajectory.International journal of environmental research and public health · 2019Review
- Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer.International journal of biomedical imaging · 2019Article
- Prometastatic Molecular Profiles in Breast Tumors From Socially Isolated Women.JNCI cancer spectrum · 2018Article
- Psychosocial Stress Exposure Disrupts Mammary Gland Development.Journal of mammary gland biology and neoplasia · 2018Article
- Analysis of Tumor Biology to Advance Cancer Health Disparity Research.The American journal of pathology · 2018Review
- Article
- Absence ofFrontiers in molecular neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Chronic social isolation is linked to increased mammary tumor growth in rodent models of breast cancer. In the C3(1)/SV40 T-antigen FVB/N (TAg) mouse model of "triple-negative" breast cancer, the heightened stress response elicited by social isolation has been associated with increased expression of metabolic genes in the mammary gland before invasive tumors develop (i.e., during the in situ carcinoma stage). To further understand the mechanisms underlying how accelerated mammary tumor growth is associated with social isolation, we separated the mammary gland adipose tissue from adjacent ductal epithelial cells and analyzed individual cell types for changes in metabolic gene expression. Specifically, increased expression of the key metabolic genes Acaca, Hk2, and Acly was found in the adipocyte, rather than the epithelial fraction. Surprisingly, metabolic gene expression was not significantly increased in visceral adipose depots of socially isolated female mice. As expected, increased metabolic gene expression in the mammary adipocytes of socially isolated mice coincided with increased glucose metabolism, lipid synthesis, and leptin secretion from this adipose depot. Furthermore, application of media that had been cultured with isolated mouse mammary adipose tissue (conditioned media) resulted in increased proliferation of mammary cancer cells relative to group-housed-conditioned media. These results suggest that exposure to a chronic stressor (social isolation) results in specific metabolic reprogramming in mammary gland adipocytes that in turn contributes to increased proliferation of adjacent preinvasive malignant epithelial cells. Metabolites and/or tumor growth-promoting proteins secreted from adipose tissue could identify biomarkers and/or targets for preventive intervention in breast cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.