Evidence map›Paper›PMID 23779051›Full record

Trial reportInternational journal of obesity (2005)2014

Sleep restriction increases the neuronal response to unhealthy food in normal-weight individuals.

M-P St-Onge, S Wolfe, M Sy, A Shechter, J Hirsch

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02835261 (Impact of Sleep Restriction on Cardiometabolic Risk Factors in Pre vs Postmenopausal Women), which is not on this map. Cited by 111 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 4 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02835261 nacompletednot on this mapstarted 2016, after this paper: background citation

Impact of Sleep Restriction on Cardiometabolic Risk Factors in Pre vs Postmenopausal Women

TypeinterventionalSponsorColumbia UniversityRan2016 to 2021Enrolled54ConditionsSleep, Cardiovascular Disease, ObesityArmsSleep Restriction
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 4 syntheses or guidelines pooled it, 226 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  4. Pooled it
  5. Trial
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  14. Review
  15. Article
  16. Examining the Role of Sleep in Body Weight Regulation and Implications for Obesity Treatment: A Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  17. Sleep deprivation engages the orexin/hypocretin system to regulate food reward seeking.The international journal of neuropsychopharmacology · 2025
    Article
  18. Article
  19. Article
  20. Review

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M-P St-Onge1] Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA [2] New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.
S Wolfe1] Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA [2] New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.
M SyDepartment of Radiology, fMRI Research Center, Columbia University, New York, NY, USA.
A Shechter1] Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA [2] New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.
J Hirsch1] Department of Radiology, fMRI Research Center, Columbia University, New York, NY, USA [2] Departments of Neuroscience and Psychology, Columbia University, New York, NY, USA.
St. Luke's-Roosevelt Hospital Center · USColumbia University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Zevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6M
OBESITY RESEARCH CENTER TRAINING PROGRAMT32DK007559 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI DYMPNA GALLAGHER · 1989 to 2026
$4.3M
Sleep deprivation and energy balanceR01HL091352 · NHLBI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI ST-ONGE, MARIE-PIERRE · 2008 to 2011
$2.7M
NCRR NIH HHS 1 UL1 RR024156NCRR NIH HHS M01 RR000032NCRR NIH HHS UL1 RR024156NHLBI NIH HHS 1R01HL091352-01A1NHLBI NIH HHS R01 HL091352NIDDK NIH HHS P30 DK026687NIDDK NIH HHS T32 DK007559
6 · The paper itself

Abstract

contextSleep restriction alters responses to food. However, the underlying neural mechanisms for this effect are not well understood.

objectiveThe purpose of this study was to determine whether there is a neural system that is preferentially activated in response to unhealthy compared with healthy foods.

participantsTwenty-five normal-weight individuals, who normally slept 7-9 h per night, completed both phases of this randomized controlled study.

interventionEach participant was tested after a period of five nights of either 4 or 9 h in bed. Functional magnetic resonance imaging (fMRI) was performed in the fasted state, presenting healthy and unhealthy food stimuli and objects in a block design. Neuronal responses to unhealthy, relative to healthy food stimuli after each sleep period were assessed and compared.

resultsAfter a period of restricted sleep, viewing unhealthy foods led to greater activation in the superior and middle temporal gyri, middle and superior frontal gyri, left inferior parietal lobule, orbitofrontal cortex, and right insula compared with healthy foods. These same stimuli presented after a period of habitual sleep did not produce marked activity patterns specific to unhealthy foods. Further, food intake during restricted sleep increased in association with a relative decrease in brain oxygenation level-dependent (BOLD) activity observed in the right insula.

conclusionThis inverse relationship between insula activity and food intake and enhanced activation in brain reward and food-sensitive centers in response to unhealthy foods provides a model of neuronal mechanisms relating short sleep duration to obesity.

Indexed as

FoodMagnetic Resonance ImagingAdultAppetiteBrainBrain MappingCuesEatingFastingFemaleHumansHungerMalePhotic StimulationRewardSleep Deprivation

Identifiers

PMID23779051
PMCPMC3883872
OpenAlexW1986570905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.