ArticleSchizophrenia bulletin2014
Prefrontal brain network connectivity indicates degree of both schizophrenia risk and cognitive dysfunction.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A meta-analysis and systematic review of single vs. multimodal neuroimaging techniques in the classification of psychosis.Molecular psychiatry · 2023Pooled it
- Cognition and resting-state functional connectivity in schizophrenia.Neuroscience and biobehavioral reviews · 2016Pooled it
- Effects of quetiapine on cognitive functioning in schizophrenia: evidence for the remyelination hypothesis?European archives of psychiatry and clinical neuroscience · 2026Article
- The intersection between psychedelics and schizophrenia spectrum disorders: Reevaluating risk and therapeutic potential.Journal of psychopharmacology (Oxford, England) · 2026Review
- Brain functional network connectivity interpolation characterizes the neuropsychiatric continuum and heterogeneity.bioRxiv : the preprint server for biology · 2026Article
- The functional connectivity between the dorsolateral prefrontal cortex and the medial prefrontal cortex underlying the association between self-control and delay discounting.Brain structure & function · 2025Article
- A Statistical Characterization of Dynamic Brain Functional Connectivity.Human brain mapping · 2025Article
- Working memory and sensory memory in subclinical high schizotypy: An avenue for understanding schizophrenia?The European journal of neuroscience · 2023Review
- Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia.BMC psychiatry · 2023Article
- Psychotic Symptom, Mood, and Cognition-associated Multimodal MRI Reveal Shared Links to the Salience Network Within the Psychosis Spectrum Disorders.Schizophrenia bulletin · 2023Article
- Impaired large-scale cortico-hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia.Frontiers in neuroscience · 2023Article
- Evidence for Schizophrenia-Specific Pathophysiology of Nicotine Dependence.Frontiers in psychiatry · 2022Article
- Baseline global brain structural and functional alterations at the time of symptom onset can predict subsequent cognitive deterioration in drug-naïve first-episode schizophrenia patients: Evidence from a follow-up study.Frontiers in psychiatry · 2022Article
- Noninvasive Brain Stimulation for Nicotine Dependence in Schizophrenia: A Mini Review.Frontiers in psychiatry · 2022Review
- Altered dynamics of the prefrontal networks are associated with the risk for postpartum psychosis: a functional magnetic resonance imaging study.Translational psychiatry · 2021Article
- The Relationship Between Abnormal Resting-State Functional Connectivity of the Left Superior Frontal Gyrus and Cognitive Impairments in Youth-Onset Drug-Naïve Schizophrenia.Frontiers in psychiatry · 2021Article
- Functional network connectivity (FNC)-based generative adversarial network (GAN) and its applications in classification of mental disorders.Journal of neuroscience methods · 2020Article
- Establishing a Causal Role for Medial Prefrontal Cortex in Reality Monitoring.Frontiers in human neuroscience · 2020Article
- Associations and Heritability of Auditory Encoding, Gray Matter, and Attention in Schizophrenia.Schizophrenia bulletin · 2019Article
- Modular Functional-Metabolic Coupling Alterations of Frontoparietal Network in Schizophrenia Patients.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveCognitive dysfunction is a core feature of schizophrenia, and persons at risk for schizophrenia may show subtle deficits in attention and working memory. In this study, we investigated the relationship between integrity of functional brain networks and performance in attention and working memory tasks as well as schizophrenia risk.
methodsA total of 235 adults representing 3 levels of risk (102 outpatients with schizophrenia, 70 unaffected first-degree relatives of persons with schizophrenia, and 63 unrelated healthy controls [HCs]) completed resting-state functional magnetic resonance imaging and a battery of attention and working memory tasks (Brief Test of Attention, Hopkins Verbal Learning Test, and Brief Visuospatial Memory Test) on the same day. Functional networks were defined based on coupling with seeds in the dorsal anterior cingulate cortex, dorsolateral prefrontal cortex (DLPFC), medial prefrontal cortex (MPFC), and primary visual cortex. Networks were then dissected into regional clusters of connectivity that were used to generate individual interaction matrices representing functional connectivity within each network.
resultsBoth patients with schizophrenia and their first-degree relatives showed cognitive dysfunction compared with HCs. First canonicals indicated an inverse relationship between cognitive performance and connectivity within the DLPFC and MPFC networks. Multivariate analysis of variance revealed multivariate main effects of higher schizophrenia risk status on increased connectivity within the DLPFC and MPFC networks.
conclusionsThese data suggest that excessive connectivity within brain networks coupled to the DLPFC and MPFC, respectively, accompany cognitive deficits in persons at risk for schizophrenia. This might reflect compensatory reactions in neural systems required for cognitive processing of attention and working memory tasks to brain changes associated with schizophrenia.
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