ArticleMucosal immunology2014
Lung-resident CD4⁺ T cells are sufficient for IL-4Rα-dependent recall immunity to Nippostrongylus brasiliensis infection.
Article in Mucosal immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
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- Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism.Mucosal immunology · 2026Article
- CD4Immunology and cell biology · 2025Review
- Intrapulmonary T Cells Are Sufficient forInternational journal of molecular sciences · 2024Article
- The emerging role of effector functions exerted by tissue-resident memory T cells.Oxford open immunology · 2024Review
- Induction of Siglec-FFrontiers in immunology · 2023Article
- IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses.JCI insight · 2022Article
- Tissue resident memory T cells in the respiratory tract.Mucosal immunology · 2022Review
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- It's a hard knock life for some: Heterogeneity in infection life history of salmonids influences parasite disease outcomes.The Journal of animal ecology · 2021Article
- Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations.PLoS pathogens · 2021Article
- Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11bMucosal immunology · 2020Article
- Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection.PLoS pathogens · 2020Article
- Tissue-resident lymphocytes: weaponized sentinels at barrier surfaces.F1000Research · 2020Review
- Host Immunity and Inflammation to Pulmonary Helminth Infections.Frontiers in immunology · 2020Review
- Impact of Helminth Infections on Female Reproductive Health and Associated Diseases.Frontiers in immunology · 2020Review
- Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring.Science advances · 2019Article
- Origins of CD4Immunology · 2019Review
- Intestinal helminth infection promotes IL-5- and CD4Mucosal immunology · 2019Article
- Lung Tissue Resident Memory T-Cells in the Immune Response toFrontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Immunity to Nippostrongylus brasiliensis reinfection requires pulmonary CD4⁺ T-cell responses. We examined whether secondary lymphoid recruited or pre-existing lung CD4⁺ T-cell populations coordinated this immunity. To do this, we blocked T-cell egress from lymph nodes using Fingolimod (FTY720). This impaired host ability to resolve a primary infection but did not change effectiveness of recall immunity. Associated with this effective recall immunity was the expansion and T helper type 2 polarization of a pre-existing pulmonary CD4⁺ T-cell population. LTβR-Ig (lymphotoxin beta-receptor fusion protein)-mediated disruption of stromal cell organization of immune cells did not disrupt this recall immunity, suggesting that protection was mediated by a pulmonary interstitial residing CD4⁺ T-cell population. Adoptive transfer of N. brasiliensis-experienced pulmonary CD4⁺ T cells from FTY720-treated wild-type or T-cell interleukin (IL)-4Rα-deficient mice demonstrated protection to be IL-4Rα dependent. These results show that pre-existing CD4⁺ T cells can drive effective recall immunity to N. brasiliensis infection independently of T-cell recruitment from secondary lymphoid organs.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.