ArticleClinics (Sao Paulo, Brazil)2013
Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats.
Article in Clinics (Sao Paulo, Brazil), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Prior exercise training and experimental myocardial infarction: A systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2020Pooled it
- Exercise Improves Heart Function after Myocardial Infarction: The Merits of AMPK.Cardiovascular drugs and therapy · 2025Review
- Prior Aerobic Exercise Training Fails to Confer Cardioprotection Under Varying Exercise Volumes in Early Post-Infarction Cardiac Remodeling in Female Rats.Biomedicines · 2025Article
- The Beneficial Role of Exercise Training for Myocardial Infarction Treatment in Elderly.Frontiers in physiology · 2020Review
- Estrogen Deprivation and Myocardial Infarction: Role of Aerobic Exercise Training, Inflammation and Metabolomics.Current cardiology reviews · 2020Review
- Do Changes in Innate Immunity Underlie the Cardiovascular Benefits of Exercise?Frontiers in cardiovascular medicine · 2019Article
- Effect of Aerobic Exercise on Treg and Th17 of Rats with Ischemic Cardiomyopathy.Journal of cardiovascular translational research · 2018Article
- Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats.Journal of cellular and molecular medicine · 2016Article
- Preventive aerobic training exerts a cardioprotective effect on rats treated with monocrotaline.International journal of experimental pathology · 2016Article
- Previous exercise training increases levels of PPAR-α in long-term post-myocardial infarction in rats, which is correlated with better inflammatory response.Clinics (Sao Paulo, Brazil) · 2016Article
- A small molecule activator of AKT does not reduce ischemic injury of the rat heart.Journal of translational medicine · 2015Article
- Cardioprotection afforded by exercise training prior to myocardial infarction is associated with autonomic function improvement.BMC cardiovascular disorders · 2014Article
- Exercise training in adverse cardiac remodeling.Pflugers Archiv : European journal of physiology · 2014Review
- Exercise training reduces cardiac dysfunction and remodeling in ovariectomized rats submitted to myocardial infarction.PloS one · 2014Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present study was performed to investigate 1) whether aerobic exercise training prior to myocardial infarction would prevent cardiac dysfunction and structural deterioration and 2) whether the potential cardiac benefits of aerobic exercise training would be associated with preserved morphological and contractile properties of cardiomyocytes in post-infarct remodeled myocardium.
methodsMale Wistar rats underwent an aerobic exercise training protocol for eight weeks. The rats were then assigned to sham surgery (SHAM), sedentary lifestyle and myocardial infarction or exercise training and myocardial infarction groups and were evaluated 15 days after the surgery. Left ventricular tissue was analyzed histologically, and the contractile function of isolated myocytes was measured. Student's t-test was used to analyze infarct size and ventricular wall thickness, and the other parameters were analyzed by the Kruskal-Wallis test followed by Dunn's test or a one-way analysis of variance followed by Tukey's test (p<0.05).
resultsMyocardial infarctions in exercise-trained animals resulted in a smaller myocardial infarction extension, a thicker infarcted wall and less collagen accumulation as compared to myocardial infarctions in sedentary animals. Myocardial infarction-induced left ventricular dilation and cardiac dysfunction, as evaluated by +dP/dt and -dP/dt, were both prevented by previous aerobic exercise training. Moreover, aerobic exercise training preserved cardiac myocyte shortening, improved the maximum shortening and relengthening velocities in infarcted hearts and enhanced responsiveness to calcium.
conclusionPrevious aerobic exercise training attenuated the cardiac dysfunction and structural deterioration promoted by myocardial infarction, and such benefits were associated with preserved cardiomyocyte morphological and contractile properties.
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