ReviewHuman vaccines & immunotherapeutics2013
Challenges of assessing the clinical efficacy of asexual blood-stage Plasmodium falciparum malaria vaccines.
Review in Human vaccines & immunotherapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01.The Journal of infectious diseases · 2016Trial
- Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya.Malaria journal · 2015Trial
- Vaccines and monoclonal antibodies: new tools for malaria control.Clinical microbiology reviews · 2024Review
- Recent Trends in Malaria Vaccine Research Globally: A Bibliometric Analysis From 2005 to 2022.Journal of parasitology research · 2024Review
- Protective efficacy and correlates of immunity of immunodominant recombinantInfection and immunity · 2023Article
- Perceptions and acceptability of the controlled human malaria infection (CHMI) model in The Gambia: a qualitative study.Scientific reports · 2023Article
- Erythrocyte membrane with CLIPPKF as biomimetic nanodecoy traps merozoites and attaches to infected red blood cells to prevent Plasmodium infection.Journal of nanobiotechnology · 2023Article
- Improvement of the antibody-dependent respiratory burst assay for assessing protective immune responses to malaria.Open biology · 2022Article
- Review
- Comparison of statistical models to estimate parasite growth rate in the induced blood stage malaria model.Malaria journal · 2017Article
- A Plasmodium vivax Plasmid DNA- and Adenovirus-Vectored Malaria Vaccine Encoding Blood-Stage Antigens AMA1 and MSP1Clinical and vaccine immunology : CVI · 2017Article
- Merozoite Antigens of Plasmodium falciparum Elicit Strain-Transcending Opsonizing Immunity.Infection and immunity · 2016Article
- Progress and prospects for blood-stage malaria vaccines.Expert review of vaccines · 2016Review
- Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection.Frontiers in microbiology · 2016Article
- Review
- Considerations for Comprehensive Analyses of Sporozoite-Based Controlled Human Malaria Infection Studies.The American journal of tropical medicine and hygiene · 2015Article
- Immunization with the MAEBL M2 Domain Protects against Lethal Plasmodium yoelii Infection.Infection and immunity · 2015Article
- Malaria Vaccines: Moving Forward After Encouraging First Steps.Current tropical medicine reports · 2015Article
- Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies.Malaria journal · 2015Article
- A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.Cell host & microbe · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In the absence of any highly effective vaccine candidate against Plasmodium falciparum malaria, it remains imperative for the field to pursue all avenues that may lead to the successful development of such a formulation. The development of a subunit vaccine targeting the asexual blood-stage of Plasmodium falciparum malaria infection has proven particularly challenging with only limited success to date in clinical trials. However, only a fraction of potential blood-stage vaccine antigens have been evaluated as targets, and a number of new promising candidate antigen formulations and delivery platforms are approaching clinical development. It is therefore essential that reliable and sensitive methods of detecting, or ruling out, even modest efficacy of blood-stage vaccines in small clinical trials be established. In this article we evaluate the challenges facing blood-stage vaccine developers, assess the appropriateness and limitations of various in vivo approaches for efficacy assessment and suggest future directions for the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.