ArticleInorganic chemistry2013
Structural optimization of Zn(II)-activated magnetic resonance imaging probes.
Article in Inorganic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Zn(II)-Responsive MRI Probe Based on an Fe(III) Macrocyclic Complex.Inorganic chemistry · 2024Article
- Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions.Angewandte Chemie (International ed. in English) · 2021Article
- Self-Immolative Activation of β-Galactosidase-Responsive Probes for In Vivo MR Imaging in Mouse Models.Angewandte Chemie (International ed. in English) · 2020Article
- High-Field Detection of Biomarkers with Fast Field-Cycling MRI: The Example of Zinc Sensing.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging.Journal of the American Chemical Society · 2019Article
- Effect of Magnetic Coupling on Water Proton Relaxivity in a Series of Transition Metal GdInorganic chemistry · 2018Article
- Fluorinated EuChemical science · 2017Article
- Intramolecular Hydrogen Bonding Restricts Gd-Aqua-Ligand Dynamics.Angewandte Chemie (International ed. in English) · 2017Article
- Magnetic barcode imaging for contrast agents.Magnetic resonance in medicine · 2017Article
- Functional nanoparticles for magnetic resonance imaging.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Gd(III)-labeled peptide nanofibers for reporting on biomaterial localization in vivo.ACS nano · 2014Article
- Lanthanide probes for bioresponsive imaging.Chemical reviews · 2014Review
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Authors and funding
6 authors.
Funding
Abstract
We report the structural optimization and mechanistic investigation of a series of bioactivated magnetic resonance imaging contrast agents that transform from low relaxivity to high relaxivity in the presence of Zn(II). The change in relaxivity results from a structural transformation of the complex that alters the coordination environment about the Gd(III) center. Here, we have performed a series of systematic modifications to determine the structure that provides the optimal change in relaxivity in response to the presence of Zn(II). Relaxivity measurements in the presence and absence of Zn(II) were used in conjunction with measurements regarding water access (namely, number of water molecules bound) to the Gd(III) center and temperature-dependent (13)C NMR spectroscopy to determine how the coordination environment about the Gd(III) center is affected by the distance between the Zn(II)-binding domain and the Gd(III) chelate, the number of functional groups on the Zn(II)-binding domain, and the presence of Zn(II). The results of this study provide valuable insight into the design principles for future bioactivated magnetic resonance probes.
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