ArticleBioconjugate chemistry2013
Inducing cancer cell death by targeting its nucleus: solid gold nanospheres versus hollow gold nanocages.
Article in Bioconjugate chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 70 citations in OpenAlex.
- Emerging strategies in radiation therapy: promises and challenges of spatial fractionation, ultra-high dose rates, and nanoparticles.Journal of physics D: Applied physics · 2025Review
- Cellular Alterations Due to Direct and Indirect Interaction of Nanomaterials with Nucleic Acids.International journal of molecular sciences · 2024Review
- Nanomaterials based on hollow gold nanospheres for cancer therapy.Regenerative biomaterials · 2024Review
- Review
- Targeted and Non-Targeted Mechanisms for Killing Hypoxic Tumour Cells-Are There New Avenues for Treatment?International journal of molecular sciences · 2021Review
- Plasmonic Nanoparticles: Advanced Researches (II).Advances in experimental medicine and biology · 2021Article
- Present and Future of Surface-Enhanced Raman Scattering.ACS nano · 2020Article
- Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy.International journal of nanomedicine · 2020Review
- Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation.Pharmaceutics · 2019Article
- Metal-basedTheranostics · 2018Review
- Antitumor Activity of Alloy and Core-Shell-Type Bimetallic AgAu Nanoparticles.Nanoscale research letters · 2017Article
- In Vitro Study of Influence of Au Nanoparticles on HT29 and SPEV Cell Lines.Nanoscale research letters · 2017Article
- Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells.International journal of nanomedicine · 2017Article
- Biological mechanisms of gold nanoparticle radiosensitization.Cancer nanotechnology · 2017Review
- Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study.International journal of nanomedicine · 2017Article
- Theoretical Comparison of Optical Properties of Near-Infrared Colloidal Plasmonic Nanoparticles.Scientific reports · 2016Article
- Standards and Methodologies for Characterizing Radiobiological Impact of High-Z Nanoparticles.Theranostics · 2016Review
- Enabling cytoplasmic delivery and organelle targeting by surface modification of nanocarriers.Nanomedicine (London, England) · 2015Review
- Review
- Nanotechnology in dentistry: prevention, diagnosis, and therapy.International journal of nanomedicine · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recently, we have shown that targeting the cancer cell nucleus with solid gold nanospheres, using a cancer cell penetrating/pro-apoptotic peptide (RGD) and a nuclear localization sequence peptide (NLS), inhibits cell division, thus leading to apoptosis. In the present work, flow cytometric analysis revealed an increase in cell death, via apoptosis and necrosis, in HSC cells upon treatment with peptide-conjugated hollow gold nanocages, compared to those treated with the peptide-conjugated solid gold nanospheres. This is consistent with a G0/G1 phase accumulation, S phase depletion, and G2/M phase depletion, as well as reduced ATP levels. Here, we investigate the possible causes for the observed enhanced cell death with the use of confocal microscopy. The fluorescence images of HSC cells treated with gold nanocages indicate the presence of reactive oxygen species, known to cause apoptosis. The formation of reactive oxygen species observed is consistent with a mechanism involving the oxidation of metallic silver on the inner cavity of the nanocage (inherent to the synthesis of the gold nanocages) to silver oxide. This oxidation is confirmed by an observed redshift in the surface plasmon resonance of the gold nanocages in cell culture medium. The silver oxide, a semiconductor known to photochemically generate hydroxyl radicals, a form of reactive oxygen species, is proposed as a mechanism for the enhanced cell death caused by gold nanocages. Thus, the enhanced cell death, via apoptosis and necrosis, observed with peptide-conjugated hollow gold nanocage-treated cells is considered to be a result of the metallic composition (silver remaining on the inner cavity) of the nanocage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.