ArticleACS chemical biology2013
Integrated metabolomics approach facilitates discovery of an unpredicted natural product suite from Streptomyces coelicolor M145.
Article in ACS chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 67 citations in OpenAlex.
- Computational mass spectrometry and genome mining guided discovery of metallophores produced by Microbulbifer.ISME communications · 2026Article
- Biosynthesis of novel desferrioxamine derivatives requires unprecedented crosstalk between separate NRPS-independent siderophore pathways.Applied and environmental microbiology · 2024Article
- Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis ofMolecules (Basel, Switzerland) · 2024Article
- Açai (Molecules (Basel, Switzerland) · 2021Article
- Mining Indonesian Microbial Biodiversity for Novel Natural Compounds by a Combined Genome Mining and Molecular Networking Approach.Marine drugs · 2021Article
- System-level understanding of gene expression and regulation for engineering secondary metabolite production in Streptomyces.Journal of industrial microbiology & biotechnology · 2020Review
- Bacterial siderophores in community and host interactions.Nature reviews. Microbiology · 2020Review
- Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics.Nature biotechnology · 2019Article
- Article
- Review
- Integration of Biochemometrics and Molecular Networking to Identify Antimicrobials in Angelica keiskei.Planta medica · 2018Article
- Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- The secreted metabolome ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Metabolite profiling of ascidian Styela plicata using LC-MS with multivariate statistical analysis and their antitumor activity.Journal of enzyme inhibition and medicinal chemistry · 2017Article
- Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.Chemical communications (Cambridge, England) · 2017Article
- Actinobacteria phylogenomics, selective isolation from an iron oligotrophic environment and siderophore functional characterization, unveil new desferrioxamine traits.FEMS microbiology ecology · 2017Article
- Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols.Journal of natural products · 2017Article
- Modern mass spectrometry for synthetic biology and structure-based discovery of natural products.Natural product reports · 2016Review
- New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans.ACS chemical biology · 2016Article
- Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.Nature biotechnology · 2016Article
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5 authors at 1 institution in 1 country.
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Abstract
Natural products exhibit a broad range of biological properties and have been a crucial source of therapeutic agents and novel scaffolds. Although bacterial secondary metabolomes are widely explored, they remain incompletely cataloged by current isolation and characterization strategies. To identify metabolites residing in unexplored chemical space, we have developed an integrated discovery approach that combines bacterial growth perturbation, accurate mass spectrometry, comparative mass spectra data analysis, and fragmentation spectra clustering for the identification of low-abundant, novel compounds from complex biological matrices. In this investigation, we analyzed the secreted metabolome of the extensively studied Actinomycete, Streptomyces coelicolor M145, and discovered a low-abundant suite of 15 trihydroxamate, amphiphilic siderophores. Compounds in this class have primarily been observed in marine microorganisms making their detection in the soil-dwelling S. coelicolor M145 significant. At least 10 of these ferrioxamine-based molecules are not known to be produced by any organism, and none have previously been detected from S. coelicolor M145. In addition, we confirmed the production of ferrioxamine D1, a relatively hydrophilic family member that has not been shown to be biosynthesized by this organism. The identified molecules are part of only a small list of secondary metabolites that have been discovered since sequencing of S. coelicolor M145 revealed that it possessed numerous putative secondary metabolite-producing gene clusters with no known metabolites. Thus, the identified siderophores represent the unexplored metabolic potential of both well-studied and new organisms that could be uncovered with our sensitive and robust approach.
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