ArticleIndian journal of endocrinology and metabolism2013
Low triiodothyronine predicts mortality in critically ill patients.
Article in Indian journal of endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Association of thyroid hormones and thyroid-stimulating hormone with mortality in adults admitted to the intensive care unit: A systematic review and meta-analysis.Journal of the Chinese Medical Association : JCMA · 2022Pooled it
- Early total triiodothyronine, illness severity, and in-hospital mortality in critically ill adults.Scientific reports · 2026Article
- Induction of type 2 and 3 deiodinase in the blood cells of critically ill patients.Endocrine connections · 2025Article
- Association between serum TSH levels and all-cause mortality in critically ill patients.Heliyon · 2024Article
- Impact of thyroid hormones on predicting the occurrence of persistent inflammation, immunosuppression, and catabolism syndrome in patients with sepsis.Frontiers in endocrinology · 2024Observational
- Relationship among Low T3 Levels, Type 3 Deiodinase, Oxidative Stress, and Mortality in Sepsis and Septic Shock: Defining Patient Outcomes.International journal of molecular sciences · 2023Article
- Preoperative thyroid hormone levels predict ICU mortality after cardiopulmonary bypass in congenital heart disease patients younger than 3 months old.BMC pediatrics · 2021Article
- Prognostic Value of Thyroid Hormone FT3 in General Patients Admitted to the Intensive Care Unit.BioMed research international · 2020Observational
- Assessment of serum zinc, selenium, and prolactin concentrations in critically ill children.Pediatric health, medicine and therapeutics · 2016Review
- Thyroid Hormone Profile in Patients With Acute Coronary Syndrome.Iranian Red Crescent medical journal · 2015Article
- Can non-thyroid illness syndrome predict mortality in lung cancer patients? A prospective cohort study.Hormones & cancer · 2014Article
- Study of Non-Thyroidal Illness Syndrome and Its Recovery in Critically Ill Patients at a Tertiary Care Centre in South India.Indian journal of endocrinology and metabolismArticle
- Serum total triiodothyronine (T3) as a predictor of mortality and morbidity in critically ill patients and its correlation of predictability with acute physiology and chronic health evaluation II score: A prospective observational study.International journal of critical illness and injury scienceArticle
- Prognostic Value of Thyroid Profile in Critical Care Condition.Indian journal of endocrinology and metabolismArticle
- Assessment of thyroid and gonadal function in liver diseases.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAlteration in thyroid hormones are seen in critically ill patients admitted to intensive care units. Our objective was to study the thyroid hormone profile, prolactin and, glycosylated hemoglobin (HbA1c) at admission and analyze their correlation with mortality. MATERIALS AND
methodsIn this single centre, prospective, observational study, 100 consecutive patients (52M; 48F) admitted to medical ICU irrespective of diagnosis were included. Patients with previous thyroid disorders and drugs affecting thyroid function were excluded. All participants underwent complete physical examination and a single fasting blood sample obtained at admission was analyzed for total triiodothyronine (T3), total thyroxine (T4), thyroid stimulating hormone (TSH), HbA1c, and prolactin. The patients were divided into two groups: Group 1 - survivors (discharged from the hospital) and Group 2 - nonsurvivors (patients succumbed to their illness inside the hospital). The data were analyzed by appropriate statistical methods and a P-value of <0.05 was considered significant.
resultsThe mean age of the participants was 58.7 ± 16.9 years and the mean duration of ICU stay was 3.3 ± 3.1 days. A total of 64 patients survived, whereas remaining 36 succumbed to their illness. The baseline demographic profile was comparable between survivors and nonsurvivors. Nonsurvivors had low T3 when compared with survivors (49.1 ± 32.7 vs. 66.2 ± 30.1, P = 0.0044). There was no significant difference observed between survivors and nonsurvivors with respect to T4, TSH, HbA1c, and prolactin.
conclusionOur study showed that low T3 is an important marker of mortality in critically ill patients. Admission HbA1c, prolactin, T4, and TSH did not vary between survivors and nonsurvivors.
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