ArticleIndian journal of endocrinology and metabolism2013
The molecular mechanisms, diagnosis and management of congenital hyperinsulinism.
Article in Indian journal of endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Case report: Duplication of theFrontiers in endocrinology · 2024Article
- Watchful waiting versus pharmacological management of small-for-gestational-age infants with hyperinsulinemic hypoglycemia.Frontiers in endocrinology · 2023Observational
- Clinical and genetic characteristics of patients with congenital hyperinsulinism in 21 non-consanguineous families from Serbia.European journal of pediatrics · 2021Article
- Sirolimus Therapy and Follow-up in a Patient with Severe Congenital Hyperinsulinism Following Subtotal PancreatectomyJournal of clinical research in pediatric endocrinology · 2021Article
- Hyperinsulinemic hypoglycemia in children and adolescents: Recent advances in understanding of pathophysiology and management.Reviews in endocrine & metabolic disorders · 2020Review
- The Genetic and Molecular Mechanisms of Congenital Hyperinsulinism.Frontiers in endocrinology · 2019Review
- Pathophysiology and aetiology of hypoglycaemic crises.The Journal of small animal practice · 2018Review
- Hyperinsulinism-hyperammonemia Syndrome in an Infant with Seizures.Balkan journal of medical genetics : BJMG · 2018Article
- Intraoperative Ultrasound: A Tool to Support Tissue-Sparing Curative Pancreatic Resection in Focal Congenital Hyperinsulinism.Frontiers in endocrinology · 2018Article
- Modeling Congenital Hyperinsulinism with ABCC8-Deficient Human Embryonic Stem Cells Generated by CRISPR/Cas9.Scientific reports · 2017Article
- Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes.Genome research · 2017Article
- Congenital hyperinsulinism and Poland syndrome in association with 10p13-14 duplication.Endocrinology, diabetes & metabolism case reports · 2017Article
- Benign Tumors and Tumorlike Lesions of the Pancreas.Surgical pathology clinics · 2016Review
- Current Status of Childhood Hyperinsulinemic Hypoglycemia in Turkey.Journal of clinical research in pediatric endocrinology · 2016Review
- A Case Series: Congenital Hyperinsulinism.International journal of endocrinology and metabolism · 2016Article
- Genotype and phenotype correlations in Iranian patients with hyperinsulinaemic hypoglycaemia.BMC research notes · 2015Article
- Delayed presentation of prolonged hyperinsulinaemic hypoglycaemia in a preterm small-for-gestational age neonate.BMJ case reports · 2013Article
- Ghrelin: much more than a hunger hormone.Current opinion in clinical nutrition and metabolic care · 2013Review
- Paternally inherited ABCC8 mutation causing diffuse congenital hyperinsulinism.Endocrinology, diabetes & metabolism case reports · 2013Article
- Hyperinsulinemic hypoglycemia syndrome in 2 dogs with bartonellosis.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Congenital hyperinsulinism (CHI) is the result of unregulated insulin secretion from the pancreatic β-cells leading to severe hypoglycaemia. In these patients it is important to make an accurate diagnosis and initiate the appropriate management so as to avoid hypoglycemic episodes and prevent the potentially associated complications like epilepsy, neurological impairment and cerebral palsy. At a genetic level abnormalities in eight different genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A and UCP2) have been reported with CHI. Loss of function mutations in ABCC8/KCNJ11 lead to the most severe forms of CHI which are usually medically unresponsive. At a histological level there are two major subgroups, diffuse and focal, each with a different genetic etiology. The focal form is sporadic in inheritance and is localized to a small region of the pancreas whereas the diffuse form is inherited in an autosomal recessive (or dominant) manner. Imaging using a specialized positron emission tomography scan with the isotope fluroine-18 L-3, 4-dihydroxyphenyalanine (18F-DOPA-PET-CT) is used to accurately locate the focal lesion pre-operatively and if removed can cure the patient from hypoglycemia. Understanding the molecular mechanisms, the histological basis, improvements in imaging modalities and surgical techniques have all improved the management of patients with CHI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.