ArticleInternational journal of applied & basic medical research2012
Neonatal sepsis: Role of a battery of immunohematological tests in early diagnosis.
Article in International journal of applied & basic medical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The Utility of Peripheral Blood Leucocyte Ratios as Biomarkers in Neonatal Sepsis: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Clinical prediction models to diagnose neonatal sepsis in low-income and middle-income countries: a scoping review.BMJ global health · 2025Article
- Article
- Diagnostic utility of combined immature and total neutrophil counts along with C-reactive protein in early detection of neonatal sepsis: A cross-sectional study.Annals of medicine and surgery (2012) · 2022Article
- The diagnostic and prognostic role of MiRNA 15b and MiRNA 378a in neonatal sepsis.Biochemistry and biophysics reports · 2021Article
- Biochemical and molecular study on serum miRNA-16a and miRNA- 451 as neonatal sepsis biomarkers.Biochemistry and biophysics reports · 2021Article
- Cord Blood Acute Phase Reactants Predict Early Onset Neonatal Sepsis in Preterm Infants.PloS one · 2017Article
- Biomarkers for sepsis: a review with special attention to India.BioMed research international · 2014Review
- A novel marker procalcitonin may help stem the antibiotic overuse in emergency setting.International journal of applied & basic medical research · 2013Article
- The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis.BioMed research internationalArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveWorldwide, many neonates with sepsis die due to lack of early diagnosis. In this study we attempt to analyze the value of various immunological and hematological parameters, singly and in combination, for the diagnosis of neonatal sepsis, with the aim being to formulate guidelines for the early diagnosis of the condition. MATERIALS AND
methodsIn this prospective study, 62 patients having clinical suspicion of neonatal sepsis were evaluated with a battery of investigations. Neonates admitted for other causes and without clinical suspicion of sepsis were selected as controls (n=40). The tests included blood culture, hemoglobin level, total and differential blood count, absolute neutrophil count, ratio of immature to total neutrophil count (I/T ratio), micro-erythrocyte sedimentation rate (m-ESR), C-reactive protein (CRP), platelet count, serum IgM level, and plasma fibrinogen level. Patients were divided into proven cases (positive blood culture) and probable cases (negative blood culture).
resultsPositive blood culture was seen in 38 cases (61.3%). Raised m-ESR (>8 mm in the first hour) was seen in 63.2% of proven and 66.7% of probable cases. I/T ratio of ≥0.2 was seen in 63.2% and 58.3% of proven and probable cases, respectively. Morphological changes in neutrophils were detected in 68.4% of proven cases and 91.7% of probable cases. Positive CRP test (≥6 mg/l) was found in 84.2% of proven cases and 100% of probable cases. Raised serum IgM, leucopenia, and neutropenia were seen in a small number of patients (11%-37%). Raised fibrinogen level (>400 mg/l) was seen in patients as well as in controls.
conclusionsThe four useful tests that we identified were m-ESR, I/T ratio, morphological changes in neutrophils, and CRP; and role of these tests in early diagnosis of neonatal sepis were statistically significant (P<.05). The most sensitive test was CRP (84%) and the most specific test was m-ESR (94%). A combination of three or all of these four tests was highly specific (95%-100%).
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