ArticlePloS one2013
Multilocus sequence typing and further genetic characterization of the enigmatic pathogen, Staphylococcus hominis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A new approach for establishing multilocus sequence typing scheme: Staphylococcus capitis as an example.BMC microbiology · 2025Article
- The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials.Scientific reports · 2025Article
- Genus-targeted markers for the taxonomic identification and monitoring of coagulase-positive and coagulase-negative Staphylococcus species.World journal of microbiology & biotechnology · 2024Article
- Molecular epidemiology and antibiotic resistance of staphylococci other thanFrontiers in microbiology · 2023Article
- Comparative Genomic Analysis of a Multidrug-ResistantPathogens (Basel, Switzerland) · 2022Article
- Characterization of genetic diversity and population structure within Staphylococcus chromogenes by multilocus sequence typing.PloS one · 2021Article
- Global Expansion of Linezolid-Resistant Coagulase-Negative Staphylococci.Frontiers in microbiology · 2021Article
- Fecal non-aureus Staphylococci are a potential cause of bovine intramammary infection.Veterinary research · 2020Article
- Staphylococcal species less frequently isolated from human clinical specimens - are they a threat for hospital patients?BMC infectious diseases · 2020Article
- Staphylococcus hominis subspecies can be identified by SDS-PAGE or MALDI-TOF MS profiles.Scientific reports · 2019Article
- Multifactorial mechanisms of the pathogenesis of methicillin-resistant Staphylococcus hominis isolated from bloodstream infections.Antonie van Leeuwenhoek · 2018Article
- Draft genome sequences of two opportunistic pathogenic strains ofStandards in genomic sciences · 2017Article
- Molecular basis of resistance to macrolides, lincosamides and streptogramins in Staphylococcus hominis strains isolated from clinical specimens.Folia microbiologica · 2016Article
- Prevalence and behavioural risk factors of Staphylococcus aureus nasal colonization in community-based injection drug users.Epidemiology and infection · 2015Article
- Biofilm formation by Staphylococcus hominis strains isolated from human clinical specimens.Folia microbiologica · 2015Article
- Antibiotic Susceptibility of Biofilm Cells and Molecular Characterisation of Staphylococcus hominis Isolates from Blood.PloS one · 2015Article
- Article
- Whole-genome sequencing reveals clonal expansion of multiresistant Staphylococcus haemolyticus in European hospitals.The Journal of antimicrobial chemotherapy · 2014Article
- Multiplex PCR assay for identification of six different Staphylococcus spp. and simultaneous detection of methicillin and mupirocin resistance.Journal of clinical microbiology · 2014Article
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10 authors.
Funding
Abstract
Staphylococcus hominis is a commensal resident of human skin and an opportunistic pathogen. The species is subdivided into two subspecies, S. hominis subsp. hominis and S. hominis subsp. novobiosepticus, which are difficult to distinguish. To investigate the evolution and epidemiology of S. hominis, a total of 108 isolates collected from 10 countries over 40 years were characterized by classical phenotypic methods and genetic methods. One nonsynonymous mutation in gyrB, scored with a novel SNP typing assay, had a perfect association with the novobiocin-resistant phenotype. A multilocus sequence typing (MLST) scheme was developed from six housekeeping gene fragments, and revealed relatively high levels of genetic diversity and a significant impact of recombination on S. hominis population structure. Among the 40 sequence types (STs) identified by MLST, three STs (ST2, ST16 and ST23) were S. hominis subsp. novobiosepticus, and they distinguished between isolates from different outbreaks, whereas 37 other STs were S. hominis subsp. hominis, one of which was widely disseminated (ST1). A modified PCR assay was developed to detect the presence of ccrAB4 from the SCCmec genetic element. S. hominis subsp. novobiosepticus isolates were oxacillin-resistant and carriers of specific components of SCCmec (mecA class A, ccrAB3, ccrAB4, ccrC), whereas S. hominis subsp. hominis included both oxacillin-sensitive and -resistant isolates and a more diverse array of SCCmec components. Surprisingly, phylogenetic analyses indicated that S. hominis subsp. novobiosepticus may be a polyphyletic and, hence, artificial taxon. In summary, these results revealed the genetic diversity of S. hominis, the identities of outbreak-causing clones, and the evolutionary relationships between subspecies and clones. The pathogenic lifestyle attributed to S. hominis subsp. novobiosepticus may have originated on more than one occasion.
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