ArticlePloS one2013
Tannins possessing bacteriostatic effect impair Pseudomonas aeruginosa adhesion and biofilm formation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 137 citations in OpenAlex.
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- Antibacterial and Antibiotic Potentiation Activities of Selected Australian Terminalia spp. Against Gastrointestinal Pathogens.Chemistry & biodiversity · 2026Article
- Potent surface antimicrobial activity of hydrolyzable tannins from Aleppo oak galls.Scientific reports · 2025Article
- Exploring the effects of phenolic compounds and essential oils in poultry: A sustainable strategy to combat Salmonella biofilm infections.Poultry science · 2025Review
- Metal-Phenolic Network-Directed Coating ofFoods (Basel, Switzerland) · 2025Article
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- Bioactive Compounds as Alternative Approaches for Preventing Urinary Tract Infections in the Era of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2025Review
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- Antimicrobial Metabolites of Caucasian Medicinal Plants as Alternatives to Antibiotics.Antibiotics (Basel, Switzerland) · 2024Review
- Ellagitannin content and anti-enterohemorrhagicHeliyon · 2024Article
- Biofilm-Inhibitory Activity of Wild Mushroom Extracts against Pathogenic Bacteria.Evidence-based complementary and alternative medicine : eCAM · 2024Article
- Phytochemical Composition, Antioxidant, Antimicrobial, Antibiofilm, and Antiquorum Sensing Potential of Methanol Extract and Essential Oil fromACS omega · 2023Article
- The Structural Changes in the Membranes ofMembranes · 2022Article
- Phytochemical profile and antimicrobial activity of the leaves and stem bark of Symphonia globulifera L.f. and Allophylus abyssinicus (Hochst.) Radlk.BMC complementary medicine and therapies · 2022Article
- Exploring changes in bacterioplankton community structure in response to tannic acid, a major component of mangrove litterfall of Sundarbans mangrove ecosystem: a laboratory mesocosm approach.Environmental science and pollution research international · 2022Article
- Effect of chemical modifications of tannins on their antimicrobial and antibiofilm effect against Gram-negative and Gram-positive bacteria.Frontiers in microbiology · 2022Article
- Characterization and low-cost preservation of Chromobacterium violaceum strain TRFM-24 isolated from Tripura state, India.Journal, genetic engineering & biotechnology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants produce many compounds that are biologically active, either as part of their normal program of growth and development or in response to pathogen attack or stress. Traditionally, Anadenanthera colubrina, Commiphora leptophloeos and Myracrodruon urundeuva have been used by communities in the Brazilian Caatinga to treat several infectious diseases. The ability to impair bacterial adhesion represents an ideal strategy to combat bacterial pathogenesis, because of its importance in the early stages of the infectious process; thus, the search for anti-adherent compounds in plants is a very promising alternative. This study investigated the ability of stem-bark extracts from these three species to control the growth and prevent biofilm formation of Pseudomonas aeruginosa, an important opportunistic pathogen that adheres to surfaces and forms protective biofilms. A kinetic study (0-72 h) demonstrated that the growth of extract-treated bacteria was inhibited up to 9 h after incubation, suggesting a bacteriostatic activity. Transmission electron microscopy and fluorescence microscopy showed both viable and nonviable cells, indicating bacterial membrane damage; crystal violet assay and scanning electron microscopy demonstrated that treatment strongly inhibited biofilm formation during 6 and 24 h and that matrix production remained impaired even after growth was restored, at 24 and 48 h of incubation. Herein, we propose that the identified (condensed and hydrolyzable) tannins are able to inhibit biofilm formation via bacteriostatic properties, damaging the bacterial membrane and hindering matrix production. Our findings demonstrate the importance of this abundant class of Natural Products in higher plants against one of the most challenging issues in the hospital setting: biofilm resilience.
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Registered trials
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