ArticlePloS one2013
Genome-wide gene expression analysis of Bordetella pertussis isolates associated with a resurgence in pertussis: elucidation of factors involved in the increased fitness of epidemic strains.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Population-Based Pertussis Incidence and Risk Factors in Infants Less Than 6 Months in Nepal.Journal of the Pediatric Infectious Diseases Society · 2017Trial
- Released palmitic acid-mediated TLR4/NF-κB activation enhances the virulence of Bordetella pertussis MT28 lineage.Nature communications · 2026Article
- Proteomic comparison of epidemic AustralianMicrobiology spectrum · 2025Article
- Pertussis-A Re-Emerging Threat Despite Immunization: An Analysis of Vaccine Effectiveness and Antibiotic Resistance.International journal of molecular sciences · 2025Review
- Vaccine antigen-based genotyping ofMicrobiology spectrum · 2025Article
- Pertussis resurgence: epidemiological trends, pathogenic mechanisms, and preventive strategies.Frontiers in immunology · 2025Review
- Article
- Comparative Evaluation of Recombinant and Acellular Pertussis Vaccines in a Murine Model.Vaccines · 2024Article
- Genomic dissection of the microevolution of Australian epidemicEmerging microbes & infections · 2022Article
- Characterization ofPathogens (Basel, Switzerland) · 2022Article
- Reinvestigating the Coughing Rat Model of Pertussis To UnderstandInfection and immunity · 2021Article
- Infant rhesus macaques as a non-human primate model of Bordetella pertussis infection.BMC infectious diseases · 2021Article
- Comparative Omics Analysis of Historic and Recent Isolates of Bordetella pertussis and Effects of Genome Rearrangements on Evolution.Emerging infectious diseases · 2021Article
- The Role of Virulence Proteins in Protection Conferred byVaccines · 2020Article
- Genome diversity and evolutionary characteristics of clinical isolates ofIranian journal of microbiology · 2020Article
- Genomic epidemiology of IranianEmerging microbes & infections · 2019Article
- Article
- Emerging of ptxP3 lineage in Bordetella pertussis strains circulating in a population in northeastern Mexico.Epidemiology and infection · 2018Article
- Strain variation and antigenic divergence among Bordetella pertussis circulating strains isolated from patients in Iran.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.Medical microbiology and immunology · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bordetella pertussis (B. pertussis) is the causative agent of whooping cough, which is a highly contagious disease in the human respiratory tract. Despite vaccination since the 1950s, pertussis remains the most prevalent vaccine-preventable disease in developed countries. A recent resurgence pertussis is associated with the expansion of B. pertussis strains with a novel allele for the pertussis toxin (ptx) promoter ptxP3 in place of resident ptxP1 strains. The recent expansion of ptxP3 strains suggests that these strains carry mutations that have increased their fitness. Compared to the ptxP1 strains, ptxP3 strains produce more Ptx, which results in increased virulence and immune suppression. In this study, we investigated the contribution of gene expression changes of various genes on the increased fitness of the ptxP3 strains. Using genome-wide gene expression profiling, we show that several virulence genes had higher expression levels in the ptxP3 strains compared to the ptxP1 strains. We provide the first evidence that wildtype ptxP3 strains are better colonizers in an intranasal mouse infection model. This study shows that the ptxP3 mutation and the genetic background of ptxP3 strains affect fitness by contributing to the ability to colonize in a mouse infection model. These results show that the genetic background of ptxP3 strains with a higher expression of virulence genes contribute to increased fitness.
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