ArticlePloS one2013
Potential usefulness of FDG PET/CT in patients with sepsis of unknown origin.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection.PloS one · 2022Article
- The role of [18F]FDG-PET/CT in gram-positive and gram-negative bacteraemia: A systematic review.Frontiers in nuclear medicine · 2022Review
- FDG-PET/CT in intensive care patients with bloodstream infection.Critical care (London, England) · 2021Article
- PET/CT Imaging for Personalized Management of Infectious Diseases.Journal of personalized medicine · 2021Review
- Occupational hazard in an immunosuppressed patient.Frontline gastroenterology · 2021Article
- Observational
- Different FDG-PET metabolic patterns of anti-AMPAR and anti-NMDAR encephalitis: Case report and literature review.Brain and behavior · 2020Review
- Clinicopathologic parameters associated with the FDG-avidity in staging of early gastric cancer using 18F-FDG PET.Medicine · 2019Observational
- Intra-abdominal sepsis: new definitions and current clinical standards.Langenbeck's archives of surgery · 2019Review
- Diagnostic Performance ofContrast media & molecular imaging · 2019Review
- Clinical utility of FDG PET/CT in acute complicated pyelonephritis-results from an observational study.European journal of nuclear medicine and molecular imaging · 2018Observational
- Role of Whole-bodyJournal of global infectious diseasesArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe role of FDG PET in the evaluation of patients with sepsis of unknown origin remains unclear. We sought to assess the value of FDG PET/CT in patients with sepsis of unknown cause and to define its priority in this group of subjects.
methodsA total of 53 patients with sepsis of unknown origin underwent FDG PET/CT within two weeks of diagnosis. All of the patients were followed up for at least 3 months after discharge to determine the clinical outcomes. The impact of FDG PET/CT was assessed according to the number of cases who had their treatment modified on the basis of the imaging results. Logistic regression analysis was used to identify the independent predictors of positive FDG PET/CT findings.
resultsOf the 53 study patients, 35 (66%) had positive FDG PET/CT findings, and 13 (25%) had their treatment modified on the basis of the imaging results. Logistic regression analysis identified normal serum aspartate aminotransferase (odds ratio [OR] = 6.134; 95% confidence interval [CI] = 1.443-26.076, P = 0.014) and increased serum alkaline phosphatase levels (OR = 5.813; 95% CI = 1.386-24.376, P = 0.016) at diagnosis as independent predictors of positive FDG PET/CT findings. A scoring system using these two covariates was developed, which defined three distinct priority groups for FDG PET/CT imaging.
conclusionOur findings suggest that FDG PET/CT may be clinically useful for the detection of occult foci of infection in patients with sepsis of unknown origin.
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