ArticlePloS one2013
Auto-antibodies and their association with clinical findings in women diagnosed with microscopic colitis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Plasma FABP2, IL-10, and LPS in Microscopic Colitis: An Exploratory Study of Their Biomarker Potential.Medicina (Kaunas, Lithuania) · 2026Article
- Autoimmune Thyroid Diseases and Microscopic Colitis: A Nationwide Matched Case-Control Study in Sweden.The Journal of clinical endocrinology and metabolism · 2025Article
- Review
- The Metabolomic Profile of Microscopic Colitis Is Affected by Smoking but Not Histopathological Diagnosis, Clinical Course, Symptoms, or Treatment.Metabolites · 2024Article
- Microscopic Colitis: Pathogenesis and Diagnosis.Journal of clinical medicine · 2023Review
- Spontaneous colonic perforation with collagenous colitis in an elderly patient.Clinical journal of gastroenterology · 2022Article
- Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility.United European gastroenterology journal · 2022Review
- Lack of autoantibodies against collagen and related proteins in collagenous colitis.BMC immunology · 2022Article
- Microscopic colitis in older adults: impact, diagnosis, and management.Therapeutic advances in chronic disease · 2022Review
- Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2021Article
- Collagenous Gastritis in Children: Incidence, Disease Course, and Associations With Autoimmunity and Inflammatory Markers.Clinical and translational gastroenterology · 2020Article
- AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis.International journal of molecular sciences · 2019Article
- Management of microscopic colitis: challenges and solutions.Clinical and experimental gastroenterology · 2019Review
- Current Approach to the Evaluation and Management of Microscopic Colitis.Current gastroenterology reports · 2017Review
- Biomarkers and Microscopic Colitis: An Unmet Need in Clinical Practice.Frontiers in medicine · 2017Review
- Anti-BMC obesity · 2017Article
- Bullous Pemphigoid with Lymphocytic Colitis: A Case Report and Short Literature Review.Dermatology and therapy · 2016Article
- New insights and challenges in microscopic colitis.Therapeutic advances in gastroenterology · 2015Review
- Microscopic colitis and reproductive factors related to exposure to estrogens and progesterone.Drug target insights · 2013Article
- Microscopic Colitis is Associated with Several Concomitant Diseases.Drug target insights · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroscopic colitis (MC) is a disease manifested by diarrhoea and is divided into collagenous and lymphocytic colitis. The aetiology is unknown, but auto-immunity is suggested. Auto-antibodies have been only rarely examined in this entity. The aim of the study was to examine the prevalence of auto-antibodies, and to examine associations between the presence of antibodies and clinical findings. METHODS AND
findingsWomen with MC verified by biopsy and younger than 73 years, at any Department of Gastroenterology, in the district of Skåne, between 2002 and 2010 were invited to participate in this study. The patients were asked to complete both a questionnaire describing their medical history and the Gastrointestinal Symptom Rating Scale (GSRS). Blood samples were collected. Anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-Saccharomyces cerevisiae antibodies (ASCA), and antibodies against glutamic acid decarboxylase (anti-GAD), islet antigens-like insulin 2 (anti-IA2), thyroid peroxidase (anti-TPO), and thyrotropin receptor (TRAK) were analysed. Of 240 women identified, 133 were finally included in the study, median age 63 (59-67) years. Apart from the MC diagnosis, 52% also suffered from irritable bowel syndrome, 31% from hypertension and 31% from allergy. The prevalence of ANA (14%), ASCA IgG (13%), and anti-TPO antibodies (14%) for these patients was slightly higher than for the general population, and were found together with other concomitant diseases. Patients had more of all gastrointestinal symptoms compared with norm values, irrespective of antibody expression.
conclusionsWomen with MC have a slightly increased prevalence of some auto-antibodies. These antibodies are not associated with symptoms, but are expressed in patients with concomitant diseases, obscuring the pathophysiology and clinical picture of MC.
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