ArticlePloS one2013
Identification of immune traits correlated with dairy cow health, reproduction and productivity.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 76 citations in OpenAlex.
- Multivariate hematological and biochemical profiling reveals conserved physiological modules in Brahman- and Charolais-crossbred beef cattle under tropical smallholder systems.Veterinary world · 2026Article
- Individual Cow Recognition Based on Ultra-Wideband and Computer Vision.Animals : an open access journal from MDPI · 2025Article
- Genome-wide associations with longevity and reproductive traits in U.S. rangeland ewes.Frontiers in genetics · 2024Article
- Plasma Metabolomic Analysis Reveals the Relationship between Immune Function and Metabolic Changes in Holstein Peripartum Dairy Cows.Metabolites · 2022Article
- Genome-Wide Association Study Provides Insights into Important Genes for Reproductive Traits in Nelore Cattle.Animals : an open access journal from MDPI · 2021Article
- Assessment of the variability of reproductive abilities of a black and white cattle using genealogical data and paratypical factors.Data in brief · 2021Article
- Monitoring and Characteristics of Major Mastitis Pathogens from Bulk Tank Milk in Korea.Animals : an open access journal from MDPI · 2020Article
- Effects of Extruded Linseed and Soybean Dietary Supplementation on Lactation Performance, First-Service Conception Rate, and Mastitis Incidence in Holstein Dairy Cows.Animals : an open access journal from MDPI · 2020Article
- The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries).PLoS genetics · 2019Article
- Genotype-by-environment interaction of fertility traits in Danish Holstein cattle using a single-step genomic reaction norm model.Heredity · 2019Article
- Comparative Evaluation of the Immune Responses in Cattle Mammary Tissues Naturally Infected with Bovine Parainfluenza Virus Type 3 and Bovine Alphaherpesvirus-1.Pathogens (Basel, Switzerland) · 2019Article
- A genome-wide association study for natural antibodies measured in blood of Canadian Holstein cows.BMC genomics · 2018Article
- Cellular and humoral immunity in a wild mammal: Variation with age & sex and association with overwinter survival.Ecology and evolution · 2016Article
- Maternal body size influences offspring immune configuration in an oviparous snake.Royal Society open science · 2016Article
- Article
- Factors affecting milk cortisol in mid lactating dairy cows.BMC veterinary research · 2015Article
- Inflammatory cytokine and acute phase protein concentrations in the peripheral blood and uterine washings of cows with subclinical endometritis in the late postpartum period.Veterinary research communications · 2015Article
- Multivariate immune defences and fitness in the wild: complex but ecologically important associations among plasma antibodies, health and survival.Proceedings. Biological sciences · 2014Article
- Current status for gastrointestinal nematode diagnosis in small ruminants: where are we and where are we going?Journal of immunology research · 2014Review
- Repeated oronasal exposure to lipopolysaccharide induced mucosal IgA responses in periparturient dairy cows.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detailed biological analyses (e.g. epidemiological, genetic) of animal health and fitness in the field are limited by the lack of large-scale recording of individual animals. An alternative approach is to identify immune traits that are associated with these important functions and can be subsequently used in more detailed studies. We have used an experimental dairy herd with uniquely dense phenotypic data to identify a range of potentially useful immune traits correlated with enhanced (or depressed) health and fitness. Blood samples from 248 dairy cows were collected at two-monthly intervals over a 10-month period and analysed for a number of immune traits, including levels of serum proteins associated with the innate immune response and circulating leukocyte populations. Immune measures were matched to individual cow records related to productivity, fertility and disease. Correlations between traits were calculated using bivariate analyses based on animal repeatability and random regression models with a Bonferroni correction to account for multiple testing. A number of significant correlations were found between immune traits and other recorded traits including: CD4(+):CD8(+) T lymphocyte ratio and subclinical mastitis; % CD8(+) lymphocytes and fertility; % CD335(+) natural killer cells and lameness episodes; and serum haptoglobin levels and clinical mastitis. Importantly these traits were not associated with reduced productivity and, in the case of cellular immune traits, were highly repeatable. Moreover these immune traits displayed significant between-animal variation suggesting that they may be altered by genetic selection. This study represents the largest simultaneous analysis of multiple immune traits in dairy cattle to-date and demonstrates that a number of immune traits are associated with health events. These traits represent useful selection markers for future programmes aimed at improving animal health and fitness.
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Registered trials
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