ArticlePloS one2013
A method for WD40 repeat detection and secondary structure prediction.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Integrative sequence-structure analysis reveals hidden WD40 domains forming stable β-propeller folds with potential biological functions in plants.Plant communications · 2026Article
- Article
- The role of the WD40-repeat protein family in cancer.Molecular cancer · 2026Review
- Genome-wide characterization of WD40 repeat proteins in cucumber reveals their functional roles in stress response and parthenocarpy.Scientific reports · 2025Article
- Genome-Wide Identification and Analysis of WD40 Family and Its Expression inInternational journal of molecular sciences · 2024Article
- Cloning and expression analysis of DnMSI1 gene in orchid speciesPlant signaling & behavior · 2022Article
- Identification of a protein unique to the genus Plasmodium that contains a WD40 repeat domain and extensive low-complexity sequence.Parasitology research · 2021Article
- Critical assessment of coiled-coil predictions based on protein structure data.Scientific reports · 2021Article
- Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Article
- WDSPdb: an updated resource for WD40 proteins.Bioinformatics (Oxford, England) · 2019Article
- Arabidopsis S2Lb links AtCOMPASS-like and SDG2 activity in H3K4me3 independently from histone H2B monoubiquitination.Genome biology · 2019Article
- Genome Wide Analysis of WD40 Proteins in Saccharomyces cerevisiae and Their Orthologs in Candida albicans.The protein journal · 2019Article
- The Cajal Body Protein WRAP53β Prepares the Scene for Repair of DNA Double-Strand Breaks by Regulating Local Ubiquitination.Frontiers in molecular biosciences · 2019Review
- Ciliary proteins Fap43 and Fap44 interact with each other and are essential for proper cilia and flagella beating.Cellular and molecular life sciences : CMLS · 2018Article
- Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA.Scientific reports · 2018Article
- Evolution of DDB1-binding WD40 (DWD) in the viridiplantae.PloS one · 2018Article
- WD40 repeat domain proteins: a novel target class?Nature reviews. Drug discovery · 2017Review
- Prokaryotic and Highly-Repetitive WD40 Proteins: A Systematic Study.Scientific reports · 2017Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
WD40-repeat proteins (WD40s), as one of the largest protein families in eukaryotes, play vital roles in assembling protein-protein/DNA/RNA complexes. WD40s fold into similar β-propeller structures despite diversified sequences. A program WDSP (WD40 repeat protein Structure Predictor) has been developed to accurately identify WD40 repeats and predict their secondary structures. The method is designed specifically for WD40 proteins by incorporating both local residue information and non-local family-specific structural features. It overcomes the problem of highly diversified protein sequences and variable loops. In addition, WDSP achieves a better prediction in identifying multiple WD40-domain proteins by taking the global combination of repeats into consideration. In secondary structure prediction, the average Q3 accuracy of WDSP in jack-knife test reaches 93.7%. A disease related protein LRRK2 was used as a representive example to demonstrate the structure prediction.
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