ArticlePloS one2013
Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 111 citations in OpenAlex.
- Post-Bariatric Hypoglycemia: Diagnosis, Mechanisms and Management-A Case Report-Based Review.Journal of clinical medicine · 2026Review
- Emerging Role of Taste Receptors, Entero-Endocrine Cells in Type 2 Diabetes and Metabolic Disorders.Nutrients · 2026Review
- Roux-en-Y Gastric Bypass is Associated With Increased Intestinal Glucose Uptake in Humans.Journal of the Endocrine Society · 2025Article
- Peptide YY in Type 2 Diabetes: A Complementary Gut Hormone with Therapeutic Potential Beyond GLP-1.Nutrients · 2025Review
- Postprandial metabolomics analysis reveals disordered serotonin metabolism in post-bariatric hypoglycemia.The Journal of clinical investigation · 2024Article
- Physical properties of food or bile redirection do not contribute to the intestinal adaptations after Roux-en-Y Gastric Bypass in rats.Obesity science & practice · 2023Article
- Regulation of body weight: Lessons learned from bariatric surgery.Molecular metabolism · 2023Review
- Article
- Mucosal and hormonal adaptations after Roux-en-Y gastric bypass.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2023Review
- Article
- Altered Glucose Metabolism and Glucose Transporters in Systemic Organs After Bariatric Surgery.Frontiers in endocrinology · 2022Article
- Gastrointestinal peptides in eating-related disorders.Physiology & behavior · 2021 · on this mapReview
- Decrease of dipeptidyl peptidase 4 activity is associated with weight loss after bariatric surgery.Obesity surgery · 2021Article
- What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?Frontiers in endocrinology · 2021Review
- Glucose transporters in the small intestine in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- Article
- Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss.Scientific reports · 2019Article
- Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.Molecular metabolism · 2019Article
- Additional effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy.Surgery today · 2019Article
- The Role of the Small Bowel in Unintentional Weight Loss after Treatment of Upper Gastrointestinal Cancers.Journal of clinical medicine · 2019Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsRoux-en-Y gastric bypass (RYGB) leads to a rapid remission of type 2 diabetes mellitus (T2DM), but the underlying mode of action remains incompletely understood. L-cell derived gut hormones such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are thought to play a central role in the anti-diabetic effects of RYGB; therefore, an improved understanding of intestinal endocrine L-cell adaptability is considered pivotal.
methodsThe full rostrocaudal extension of the gut was analyzed in rats after RYGB and in sham-operated controls ad libitum fed or food restricted to match the body weight of RYGB rats. Total number of L-cells, as well as regional numbers, densities and mucosa volumes were quantified using stereological methods. Preproglucagon and PYY mRNA transcripts were quantified by qPCR to reflect the total and relative hormone production capacity of the L-cells.
resultsRYGB surgery induced hypertrophy of the gut mucosa in the food exposed regions of the small intestine coupled with a doubling in the total number of L-cells. No changes in L-cell density were observed in any region regardless of surgery or food restriction. The total gene expression capacity of the entire gut revealed a near 200% increase in both PYY and preproglucagon mRNA levels in RYGB rats associated with both increased L-cell number as well as region-specific increased transcription per cell.
conclusionsCollectively, these findings indicate that RYGB in rats is associated with gut hypertrophy, an increase in L-cell number, but not density, and increased PYY and preproglucagon gene expression. This could explain the enhanced gut hormone dynamics seen after RYGB.
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