ArticlePloS one2013
Role of NK cell subsets in organ-specific murine melanoma metastasis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Role of T cells in liver metastasis.Cell death & disease · 2024Review
- Melanoma Cell Reprogramming and Awakening of Antitumor Immunity as a Fingerprint of Hyper-Harmonized Hydroxylated Fullerene Water Complex (3HFWC) and Hyperpolarized Light ApplicationNanomaterials (Basel, Switzerland) · 2023Article
- The effect of organ-specific tumor microenvironments on response patterns to immunotherapy.Frontiers in immunology · 2022Review
- Targeting the cMET pathway to enhance immunotherapeutic approaches for mUM patients.Frontiers in oncology · 2022Review
- The immunological and metabolic landscape in primary and metastatic liver cancer.Nature reviews. Cancer · 2021Review
- Correlation of tumor-infiltrating immune cells of melanoma with overall survival by immunogenomic analysis.Cancer medicine · 2020Article
- Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice.European journal of immunology · 2020Article
- Association of Germline Variants in Natural Killer Cells With Tumor Immune Microenvironment Subtypes, Tumor-Infiltrating Lymphocytes, Immunotherapy Response, Clinical Outcomes, and Cancer Risk.JAMA network open · 2019Article
- Inflammation: A key process in skin tumorigenesis.Oncology letters · 2019Review
- Natural killer cell monitoring in cutaneous melanoma - new dynamic biomarker.Oncology letters · 2019Article
- The Important Role of Dendritic Cell (DC) in iNKT-Mediated Modulation of NK Cell Function in Chlamydia pneumoniae Lung Infection.Mediators of inflammation · 2019Article
- Chronic Ly49H Receptor EngagementFrontiers in immunology · 2019Article
- Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung.Cancer immunology, immunotherapy : CII · 2018Article
- The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- The immune system in cancer metastasis: friend or foe?Journal for immunotherapy of cancer · 2017Review
- CD97 promotion of gastric carcinoma lymphatic metastasis is exosome dependent.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CD107a.Cellular & molecular immunology · 2016Article
- Premetastatic niche formation in the liver: emerging mechanisms and mouse models.Journal of molecular medicine (Berlin, Germany) · 2015Review
- Inflammation markers in cutaneous melanoma - edgy biomarkers for prognosis.Discoveries (Craiova, Romania) · 2015Review
- Lung microenvironment promotes the metastasis of human hepatocellular carcinoma cells to the lungs.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Tumor metastasis plays a major role in the morbidity and mortality of cancer patients. Among solid tumors that undergo metastasis, there is often a predilection to metastasize to a particular organ with, for example, prostate cancer preferentially metastasizing to bones and colon cancer preferentially metastasizing to the liver. Although many factors are thought to be important in establishing permissiveness for metastasis, the reasons for organ-specific predilection of each tumor are not understood. Using a B16 murine melanoma model, we tested the hypothesis that organ-specific NK cell subsets play a critical role in organ-specific metastasis of this tumor. Melanoma cells, given intravenously, readily colonized the lungs but not the liver. NK cell depletion (either iatrogenically or by using genetically targeted mice) resulted in substantial hepatic metastasis. Analysis of NK cell subsets, defined by the differential expression of a combination of CD27 and CD11b, indicated a significant difference in the distribution of NK cell subsets in the lung and liver with the mature subset being dominant in the lung and the immature subset being dominant in the liver. Several experimental approaches, including adoptive transfer, clearly indicated that the immature hepatic NK cell subset, CD27+ CD11b-, was protective against liver metastasis; this subset mediated its protection by a perforin-dependent cytotoxic mechanism. In contrast, the more mature NK cell subsets were more efficient at reducing pulmonary tumor load. These data indicate that organ-specific immune responses may play a pivotal role in determining the permissiveness of a given organ for the establishment of a metastatic niche.
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