ArticlePloS one2013
Distribution of recombination hotspots in the human genome--a comparison of computer simulations with real data.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Presence of recombination hotspots throughout SLC6A3.PloS one · 2019Trial
- The fine-scale recombination rate variation and associations with genomic features in a butterfly.Genome research · 2023Article
- Assessment and Distribution of Runs of Homozygosity in Horse Breeds Representing Different Utility Types.Animals : an open access journal from MDPI · 2022Article
- Quinoa genome assembly employing genomic variation for guided scaffolding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Genetic differentiation and intrinsic genomic features explain variation in recombination hotspots among cocoa tree populations.BMC genomics · 2020Article
- The breakdown of genomic ancestry blocks in hybrid lineages given a finite number of recombination sites.Evolution; international journal of organic evolution · 2018Article
- What drives the evolution of condition-dependent recombination in diploids? Some insights from simulation modelling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- The potential of shifting recombination hotspots to increase genetic gain in livestock breeding.Genetics, selection, evolution : GSE · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination is the main cause of genetic diversity. Thus, errors in this process can lead to chromosomal abnormalities. Recombination events are confined to narrow chromosome regions called hotspots in which characteristic DNA motifs are found. Genomic analyses have shown that both recombination hotspots and DNA motifs are distributed unevenly along human chromosomes and are much more frequent in the subtelomeric regions of chromosomes than in their central parts. Clusters of motifs roughly follow the distribution of recombination hotspots whereas single motifs show a negative correlation with the hotspot distribution. To model the phenomena related to recombination, we carried out computer Monte Carlo simulations of genome evolution. Computer simulations generated uneven distribution of hotspots with their domination in the subtelomeric regions of chromosomes. They also revealed that purifying selection eliminating defective alleles is strong enough to cause such hotspot distribution. After sufficiently long time of simulations, the structure of chromosomes reached a dynamic equilibrium, in which number and global distribution of both hotspots and defective alleles remained statistically unchanged, while their precise positions were shifted. This resembles the dynamic structure of human and chimpanzee genomes, where hotspots change their exact locations but the global distributions of recombination events are very similar.
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