ArticlePloS one2013
Functional and immunological relevance of Anaplasma marginale major surface protein 1a sequence and structural analysis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Global Trends in Vaccine Research onMicroorganisms · 2026Review
- Molecular detection and characterization of Anaplasma marginale in cattle from the Lower Shabelle Region of Somalia.Parasites & vectors · 2026Article
- Nomenclature, classification, and in-silico structural analysis of MSP1a variants of Anaplasma marginale.PloS one · 2026Article
- Molecular Prevalence and Genetic Diversity Based onLife (Basel, Switzerland) · 2023Article
- Characterization of strains ofFrontiers in veterinary science · 2022Article
- Epidemiology and genotyping of Anaplasma marginale and co-infection with piroplasms and other Anaplasmataceae in cattle and buffaloes from Egypt.Parasites & vectors · 2020Article
- Ticks and Tick-Borne Diseases in Cuba, Half a Century of Scientific Research.Pathogens (Basel, Switzerland) · 2020Review
- A nearest-neighbors network model for sequence data reveals new insight into genotype distribution of a pathogen.BMC bioinformatics · 2018Article
- Co-infections with multiple genotypes of Anaplasma marginale in cattle indicate pathogen diversity.Parasites & vectors · 2018Article
- Article
- Insight into the genetic diversity of Anaplasma marginale in cattle from ten provinces of China.Parasites & vectors · 2017Article
- Characterization of Anaplasma ovis strains using the major surface protein 1a repeat sequences.Parasites & vectors · 2017Article
- Comparison of three nucleic acid-based tests for detectingThe Onderstepoort journal of veterinary research · 2017Article
- Molecular diagnosis and genetic diversity of tick-borne Anaplasmataceae agents infecting the African buffalo Syncerus caffer from Marromeu Reserve in Mozambique.Parasites & vectors · 2016Article
- Article
- Anaplasma marginale: Diversity, Virulence, and Vaccine Landscape through a Genomics Approach.BioMed research international · 2016Review
- Control of tick infestations and pathogen prevalence in cattle and sheep farms vaccinated with the recombinant Subolesin-Major Surface Protein 1a chimeric antigen.Parasites & vectors · 2014Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A. marginale strains based on N-terminal tandem repeats and a 5'-UTR microsatellite located in the msp1a gene. The MSP1a tandem repeats contain immune relevant elements and functional domains that bind to bovine erythrocytes and tick cells, thus providing information about the evolution of host-pathogen and vector-pathogen interactions. Here we propose one nomenclature for A. marginale strain classification based on MSP1a. All tandem repeats among A. marginale strains were classified and the amino acid variability/frequency in each position was determined. The sequence variation at immunodominant B cell epitopes was determined and the secondary (2D) structure of the tandem repeats was modeled. A total of 224 different strains of A. marginale were classified, showing 11 genotypes based on the 5'-UTR microsatellite and 193 different tandem repeats with high amino acid variability per position. Our results showed phylogenetic correlation between MSP1a sequence, secondary structure, B-cell epitope composition and tick transmissibility of A. marginale strains. The analysis of MSP1a sequences provides relevant information about the biology of A. marginale to design vaccines with a cross-protective capacity based on MSP1a B-cell epitopes.
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