ArticleProceedings of the National Academy of Sciences of the United States of America2013
Molecular hyperdiversity defines populations of the nematode Caenorhabditis brenneri.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64 citing papers in PubMed.
- T2T genomes ofGenome research · 2026Article
- The highly heterozygous European amphioxus (Branchiostoma lanceolatum) at the edge of panmixia.PLoS genetics · 2026Article
- Article
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Variation in inbreeding depression within and among Caenorhabditis species.G3 (Bethesda, Md.) · 2025Article
- Comparative Analyses of Four Reference Genomes Reveal Exceptional Diversity and Weak Linked Selection in the Yellow Monkeyflower (Mimulus guttatus) Complex.Molecular ecology resources · 2025Article
- Phylogenomic timetree-calibrated speciation clocks for Caenorhabditis nematodes reveal slow but disproportionate accumulation of post-zygotic reproductive isolation.PLoS genetics · 2025Article
- Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos.Current biology : CB · 2025Article
- Hybrid incompatibility emerges at the one-cell stage in interspeciesbioRxiv : the preprint server for biology · 2025Article
- Article
- The long and short of hyperdivergent regions.Trends in genetics : TIG · 2025Review
- Pervasive Conservation of Intron Number and Other Genetic Elements Revealed by a Chromosome-level Genome Assembly of the Hyper-polymorphic Nematode Caenorhabditis brenneri.Genome biology and evolution · 2025Article
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Pervasive conservation of intron number and other genetic elements revealed by a chromosome-level genomic assembly of the hyper-polymorphic nematodebioRxiv : the preprint server for biology · 2024Article
- Patterns of Genomic Diversity in a Fig-Associated Close Relative of Caenorhabditis elegans.Genome biology and evolution · 2024Article
- Parthenogenomics: Insights on mutation rates and nucleotide diversity in parthenogeneticEcology and evolution · 2024Article
- Gene presence/absence variation iniScience · 2023Article
- A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva.PLoS genetics · 2023Article
- Genome Size Changes by Duplication, Divergence, and Insertion in Caenorhabditis Worms.Molecular biology and evolution · 2023Article
- A Blind-Identification Test onPlants (Basel, Switzerland) · 2023Article
4 more citing papers are in PubMed but not listed here.
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Abstract
The biology of Sydney Brenner's eponymous species of nematode, Caenorhabditis brenneri, is little known to science, despite its famous sibling Caenorhabditis elegans. Here we demonstrate that C. brenneri harbors the most molecular diversity of any eukaryote, with its 14.1% of polymorphic synonymous sites between individuals being 150-fold greater than humans and most comparable to hyperdiverse bacteria. This diversity is not an artifact of cryptic species divergence but reflects an enormous pan-tropical population, confirmed by fully viable genetic crosses between continents, extensive intralocus recombination, selection on codon use, and only weak geographic genetic structure. These findings in an animal galvanize tests of theory about the evolution of complexity in genomes and phenotypes and enable molecular population genetics methods to finely resolve uncharacterized functional noncoding elements.
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