ArticleAnatomical record (Hoboken, N.J. : 2007)2013
Idiopathic microscopic colitis of rhesus macaques: quantitative assessment of colonic mucosa.
Article in Anatomical record (Hoboken, N.J. : 2007), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- A review of chronic enterocolitis of rhesus macaques (Frontiers in veterinary science · 2026Review
- Multicenter Analysis of the Attributable Diarrhea Risk and Odds Ratios of Pathogens in Rhesus Macaques (Macaca mulatta) Using Multiplex PCR Gastrointestinal Panel Testing and Conventional Fecal Culture.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Evaluation of commercial diets on fecal consistency and defecation frequency in rhesus macaques (Macaca mulatta) with chronic intermittent idiopathic diarrhea.Laboratory animal research · 2025Article
- AI for rapid identification of major butyrate-producing bacteria in rhesus macaques (Macaca mulatta).Animal microbiome · 2025Article
- A rapid, affordable, and reliable method for profiling microbiome biomarkers from fecal images.iScience · 2024Article
- Diversity ofmSphere · 2024Article
- Characterization of idiopathic chronic diarrhea and associated intestinal inflammation and preliminary observations of effects of vagal nerve stimulation in a non-human primate.Neurogastroenterology and motility · 2024Article
- Analysis of cell populations in the normal rhesus macaque (Veterinary pathology · 2024Article
- Evidence of potentialMicrobial genomics · 2023Article
- Early-life behavioral features are associated with chronic emesis in rhesus macaques (Macaca mulatta).American journal of primatology · 2023Article
- Effects of pair housing on behavior, cortisol, and clinical outcomes during quarantine-like procedures for rhesus macaques (Macaca mulatta).Journal of medical primatology · 2023Article
- Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques.Toxicologic pathology · 2022Review
- Idiopathic Chronic Diarrhea in Rhesus Macaques Is Not Associated with Enteric Viral Infections.Viruses · 2021Article
- Colon volvulus in rhesus macaques (Macaca mulatta) at the Oregon National Primate Research Center-Retrospective analysis.Journal of medical primatology · 2021Article
- Evaluation of the guaiac fecal occult blood test for detection of gastrointestinal bleeding in the rhesus macaque (Macaca mulatta).Journal of medical primatology · 2020Article
- Fecal metatranscriptomics of macaques with idiopathic chronic diarrhea reveals altered mucin degradation and fucose utilization.Microbiome · 2019Article
- Rotavirus is associated with decompensated diarrhea among young rhesus macaques (Macaca mulatta).American journal of primatology · 2019Article
- Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity.PloS one · 2019Article
- Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.American journal of physiology. Heart and circulatory physiology · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Idiopathic chronic diarrhea (ICD) is a common cause of morbidity and mortality among juvenile rhesus macaques. While lesions may be absent at colonoscopy, the histopathologic evaluation of the biopsy specimens is consistent with human macroscopic colitis (MC). In this study, we developed an isotropic uniform random sampling method to evaluate macroscopic and microscopic changes and applied it on proximal ascending colon in monkeys. Colonic tissue and peripheral blood specimens were collected from six MC and six control juvenile macaques at necropsy. Uniform random samples were collected from the colon using punch biopsy tools. The volume of epithelium and lamina propria were estimated in thick (25 µm) sections using point probes and normalized to the area of muscularis mucosae. Our data suggests a significant increase of the Vs of the lamina propria (1.9-fold, P = 0.02) and epithelium (1.4-fold, P = 0.05) in subjects with MC. The average colonic surface mucosa area in the MC monkeys increased 1.4-fold over the controls (P = 0.02). The volume of the proximal colon in animals with MC showed a 2.4-fold increase over the non-diarrhea control monkeys (P = 0.0001). Cytokine, chemokine, and growth factor levels in peripheral blood were found to be correlated with the volume estimate of the lamina propria and epithelium. We found that ICD in macaques has features which simulates human MC and can be used as a spontaneous animal model for human MC. Furthermore, this developed sampling method can be used for unbiased preclinical evaluation of therapeutics in this animal model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.