ArticlePsychopharmacology2013
Age-dependent effects of stress on ethanol-induced motor activity in rats.
Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Neuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking.Psychoneuroendocrinology · 2025Article
- Gestational hypoxia in late pregnancy differentially programs subcortical brain maturation in male and female rat offspring.Biology of sex differences · 2022Article
- Adolescent exposure to delta-9-tetrahydrocannabinol and ethanol heightens sensitivity to fear stimuli.Behavioural brain research · 2021Article
- Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood.Oxidative medicine and cellular longevity · 2018Article
- Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience.Frontiers in psychology · 2018Review
- Effects of environmental enrichment upon ethanol-induced conditioned place preference and pre-frontal BDNF levels in adolescent and adult mice.Scientific reports · 2017Article
- Age-Dependent Susceptibility to Alcohol-Induced Cerebral Artery Constriction.Journal of drug and alcohol research · 2016Article
- Response to stress in Drosophila is mediated by gender, age and stress paradigm.Stress (Amsterdam, Netherlands) · 2015Article
- Relationship between ethanol-induced activity and anxiolysis in the open field, elevated plus maze, light-dark box, and ethanol intake in adolescent rats.Behavioural brain research · 2014Article
- Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis.Psychopharmacology · 2014Review
- Experimental Evidence on Age-related Differential Outcomes Associated With Substance Abuse.Basic and clinical neuroscienceReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleIt is important to study age-related differences that may put adolescents at risk for alcohol-related problems. Adolescents seem less sensitive to the aversive effects of ethanol than adults. Less is known of appetitive effects of ethanol and stress modulation of these effects.
objectivesThis study aims to describe the effects of acute social or restraint stress on ethanol-precipitated locomotor activity (LMA), in adolescent and adult rats. Effects of activation of the kappa system on ethanol-induced LMA were also evaluated.
methodsAdolescent or adult rats were restrained for 90 min, exposed to social deprivation stress for 90 or 180 min or administered with the kappa agonist U62,066E before being given ethanol, and assessed for LMA.
resultsAdolescents were significantly more sensitive to the stimulating, and less sensitive to the sedative, effects of ethanol than adults. Basal locomotion was significantly increased by social deprivation stress in adult, but not in adolescent, rats. U62,066E significantly reduced basal and ethanol-induced locomotion in the adolescents. Corticosterone and progesterone levels were significantly higher in adolescents than in adults.
conclusionsAdolescents exhibit greater sensitivity to ethanol-induced LMA and reduced sensitivity to ethanol-induced motor sedation than adult rats. Ethanol's effects on motor activity were not affected by acute stress. Unlike adults, adolescents were insensitive to acute restraint and social deprivation stress but exhibited motor depression after activation of the endogenous kappa opioid receptor system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.