ArticleInternational orthopaedics2013
Identification of silent prosthetic joint infection: preliminary report of a prospective controlled study.
Article in International orthopaedics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Accuracy of diagnostic tests for prosthetic joint infection: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Pooled it
- Two-stage revision for the culture-negative infected total hip arthroplasty : A comparative study.The bone & joint journal · 2018Trial
- The boundary between microbial detection and implant-related infection: a structured narrative review of analytical credibility, biological persistence, host response, and clinical causality.Archives of orthopaedic and trauma surgery · 2026Review
- Difficulty of diagnostic accuracy of periprosthetic joint infection: a retrospective analysis of revision surgery of total hip arthroplasty and total knee arthroplasty in a tertiary hospital.BMC musculoskeletal disorders · 2024Article
- Native intra-articular knee microbiome is a matter of facts: a systematic review of clinical evidence.EFORT open reviews · 2024Article
- Single-stage total hip arthroplasty after failed fixation of proximal femoral fractures: an increased risk for periprosthetic joint infections?Archives of orthopaedic and trauma surgery · 2022Article
- Occult prosthetic aortic valve endocarditis caused byAnnals of the Royal College of Surgeons of England · 2022Article
- Article
- Long-term outcome of two-stage revision surgery after hip and knee prosthetic joint infections: an observational study.Journal of bone and joint infection · 2021Article
- Reengineering Bone-Implant Interfaces for Improved Mechanotransduction and Clinical Outcomes.Stem cell reviews and reports · 2020Review
- hBMSC-Derived Extracellular Vesicles Attenuate IL-1β-Induced Catabolic Effects on OA-Chondrocytes by Regulating Pro-inflammatory Signaling Pathways.Frontiers in bioengineering and biotechnology · 2020Article
- Understanding Biofilms and Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated Infections.Infectious disease clinics of North America · 2018Review
- Superiority of the sonication method against conventional periprosthetic tissue cultures for diagnosis of prosthetic joint infections.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018Article
- A Review of the Literature on Culture-Negative Periprosthetic Joint Infection: Epidemiology, Diagnosis and Treatment.Knee surgery & related research · 2017Review
- Sonication contribution to identifying prosthetic joint infection with Ralstonia pickettii: a case report and review of the literature.BMC musculoskeletal disorders · 2017Review
- Diagnosis of periprosthetic joint infection using alpha-defensin test or multiplex-PCR: ideal diagnostic test still not found.International orthopaedics · 2017Article
- Prosthetic joint and implant contamination caused by Ralstonia pickettii: a report of three cases٭.SICOT-J · 2017Article
- Remote transient Lactobacillus animalis bacteremia causing prosthetic hip joint infection: a case report.BMC infectious diseases · 2016Article
- Propionibacterium prosthetic joint infection: experience from a retrospective database analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2016Article
- Comparison of cultures and 16S rRNA sequencing for identification of bacteria in two-stage revision arthroplasties: preliminary report.BMC musculoskeletal disorders · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe will test the hypothesis that ultrasound supported by polymerase chain reaction (PCR) could improve bacterial identification in non-infected prosthetic joint loosening. The aim was to detect bacterial species in non-infected prosthetic joint loosening using ultrasound and 16S rRNA gene sequencing.
methodsA total of 16 patients (11 women and five men) aged 46-80 years (mean age 65.7) with diagnosed knee or hip implant loosening (mean implant survival of 102.1 months) were investigated. Bacterial culture and DNA sequencing were used to detect bacteria on the surface of failed implants removed during revision arthroplasty. The results of pre- and intraoperative culture and DNA sequencing were compared. Histopathological analysis was also performed.
resultsThe number of positive cultures rises with a higher level of C-reactive protein (CRP). The results of the cultures from synovial fluid obtained through joint aspiration were consistent with sonicates from components of prostheses in 12 cases (75%). Bacterial DNA was found in 90% of patients with negative synovial fluid culture. PCR revealed two or more bacterial species, often of the same genus: Ralstonia pickettii, Pseudomonas spp., Brevibacterium spp., Lactobacillus spp., Propionibacterium spp. and Staphylococcus spp.These are micro-organisms present in the environment or on the human body and often associated with compromised immunity.
conclusionsThe ultrasound procedure followed by PCR and sequencing improve bacterial identification in silent prosthetic joint infection. The lack of clinical signs of infection and negative preoperative and intraoperative cultures do not exclude the presence of micro-organisms on the implants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.