ArticleDevelopmental psychobiology2015
Neuroendocrine coupling across adolescence and the longitudinal influence of early life stress.
Article in Developmental psychobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparison of central precocious puberty frequency before and during COVID-19: a systematic review and meta-analysis.BMC endocrine disorders · 2024Pooled it
- Adverse Childhood Experiences and Early Pubertal Timing Among Girls: A Meta-Analysis.International journal of environmental research and public health · 2019Pooled it
- The association between pubertal timing and diurnal cortisol activity in middle adolescence.Stress (Amsterdam, Netherlands) · 2026Article
- Steroids, stress, and body mass index interact to accelerate female pubertal development.The Journal of clinical endocrinology and metabolism · 2026Article
- Secular trends and ethnic disparities in age at menarche among ethnic minority girls in China: a 35-year nationwide repeated cross-sectional study from 1985 to 2019.Journal of global health · 2026Article
- The sex-specific role of adrenal androgens in youth psychopathology.Translational psychiatry · 2026Article
- Mixed evidence for stress effects on cortisol-testosterone coupling in Syrian refugee and Jordanian non-refugee adolescents.Psychoneuroendocrinology · 2026Article
- Maternal History of Child Maltreatment Predicts Dysregulated Offspring Stress Response System Functioning.Child maltreatment · 2025Article
- Positive Cortisol-Testosterone Hormonal Coupling Among Adolescents in Argentina and Jordan.American journal of biological anthropology · 2025Article
- HPA axis dysregulation and postpartum depression and anxiety symptoms in breastfeeding vs bottle-feeding parents.Psychoneuroendocrinology · 2025Article
- Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences.Frontiers in neuroendocrinology · 2024Review
- Small for gestational age and age at menarche in a contemporary population-based U.S. sample.PloS one · 2024Article
- Profiles of diurnal cortisol and DHEA regulation among children: Associations with maltreatment experiences, symptomatology, and positive adaptation.Development and psychopathology · 2023Article
- Developmental pathways from child maltreatment to adolescent pregnancy: A multiple mediational model.Development and psychopathology · 2023Article
- Longitudinal patterns of neuroendocrine coupling from middle childhood to early adolescence.Developmental psychobiology · 2022Article
- A dual-system, machine-learning approach reveals how daily pubertal hormones relate to psychological well-being in everyday life.Developmental cognitive neuroscience · 2022Article
- Generalist genes and specialist environments for adolescent internalizing and externalizing problems: A test of severity and directionality.Development and psychopathology · 2022Article
- Capturing the dynamic nature of stress exposure in the Pittsburgh Girls Study.SSM - population health · 2021Article
- Social and Biological Transgenerational Underpinnings of Adolescent Pregnancy.International journal of environmental research and public health · 2021Review
- Childhood Socioeconomic Status and Menarche: A Prospective Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Drawing on conceptual models illustrating the advantages of a multisystemic, interactive, developmental approach to understanding development, the present study examines the covariation of stress and sex hormones across the adolescent transition and the effect of early life stress (ELS) on neuroendocrine coupling to gain insight into atypical development. Morning levels of cortisol, testosterone, and dehydroepiandrosterone (DHEA) were assessed at ages 11, 13, and 15; ELS was assessed during the infancy and preschool periods. Hierarchical linear modeling revealed that cortisol-DHEA coupling patterns progressed to tight, positive coupling across adolescence. Cortisol-testosterone coupling was positive at age 11 but became more negative at ages 13 and 15. Exposure to ELS resulted in more adultlike neuroendocrine coupling patterns earlier in life than non-exposed youth; however the effect of ELS on cortisol-testosterone coupling was unique to girls. Results illustrate trajectories of neuroendocrine coupling that may be unique to adolescence. Moderation by ELS suggests that early stress exposure may prompt earlier adultlike neuroendocrine coupling, particularly within girls, which may contribute to early pubertal development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.