ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2014
PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Research progress on the role and mechanism of DNA damage repair in germ cell development.Frontiers in endocrinology · 2023Pooled it
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- Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection.Epigenetics · 2024Article
- HPV16-miRNAs exert oncogenic effects through enhancers in human cervical cancer.Cancer cell international · 2024Article
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- Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer.Clinical epigenetics · 2021Article
- Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia.Infectious agents and cancer · 2021Article
- Long intergenic noncoding RNA LINC00284 knockdown reduces angiogenesis in ovarian cancer cellsFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- The use of molecular markers for cervical screening of women living with HIV in South Africa.AIDS (London, England) · 2019Article
- Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells.Scientific reports · 2019Article
- Stressful Newborn Memories: Pre-Conceptual,Frontiers in psychiatry · 2019Review
- HPV16-Related Cervical Cancers and Precancers Have Increased Levels of Host Cell DNA Methylation in Women Living with HIV.International journal of molecular sciences · 2018Article
- A comprehensive overview of genomic imprinting in breast and its deregulation in cancer.Nature communications · 2018Review
- Detection of hypermethylated genes as markers for cervical screening in women living with HIV.Journal of the International AIDS Society · 2018Article
- DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions.International journal of cancer · 2018Article
- Network analyses elucidate the role of SMYD3 in esophageal squamous cell carcinoma.FEBS open bio · 2017Article
- Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?Epigenetics · 2017Article
- Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer.Oncotarget · 2016Article
- Article
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
introductionAlthough most invasive cervical cancer (ICC) harbor <20 human papillomavirus (HPV) genotypes, use of HPV screening to predict ICC from HPV has low specificity, resulting in multiple and costly follow-up visits and overtreatment. We examined DNA methylation at regulatory regions of imprinted genes in relation to ICC and its precursor lesions to determine if methylation profiles are associated with progression of HPV-positive lesions to ICC. MATERIALS AND
methodsWe enrolled 148 controls, 38 CIN and 48 ICC cases at Kilimanjaro Christian Medical Centre from 2008 to 2009. HPV was genotyped by linear array and HIV-1 serostatus was tested by two rapid HIV tests. DNA methylation was measured by bisulfite pyrosequencing at regions regulating eight imprinted domains. Logistic regression models were used to estimate odd ratios.
resultsAfter adjusting for age, HPV infection, parity, hormonal contraceptive use, and HIV-1 serostatus, a 10 % decrease in methylation levels at an intragenic region of IGF2 was associated with higher risk of ICC (OR 2.00, 95 % CI 1.14-3.44) and cervical intraepithelial neoplasia (CIN) (OR 1.51, 95 % CI 1.00-2.50). Methylation levels at the H19 DMR and PEG1/MEST were also associated with ICC risk (OR 1.51, 95 % CI 0.90-2.53, and OR 1.44, 95 % CI 0.90-2.35, respectively). Restricting analyses to women >30 years further strengthened these associations.
conclusionsWhile the small sample size limits inference, these findings show that altered DNA methylation at imprinted domains including IGF2/H19 and PEG1/MEST may mediate the association between HPV and ICC risk.
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