ArticleMolecular and cellular biology2013
Variable requirements for DNA-binding proteins at polycomb-dependent repressive regions in human HOX clusters.
Article in Molecular and cellular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Decoding gene responsiveness to synthetic chromatin reader-actuators with multi-modal epigenomic profiling.NPJ systems biology and applications · 2026Article
- Epigenetic Regulation by Polycomb Complexes from Drosophila to Human and Its Relation to Communicable Disease Pathogenesis.International journal of molecular sciences · 2022Review
- Review
- Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming.Annual review of biochemistry · 2020Review
- YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells.iScience · 2018Article
- Role of HOX Genes in Stem Cell Differentiation and Cancer.Stem cells international · 2018Review
- Molecular structures guide the engineering of chromatin.Nucleic acids research · 2017Article
- Multitasking by Polycomb response elements.Genes & development · 2017Article
- Review
- Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2.Nature communications · 2015Article
- BAF250a Protein Regulates Nucleosome Occupancy and Histone Modifications in Priming Embryonic Stem Cell Differentiation.The Journal of biological chemistry · 2015Article
- Histone H3 mutations--a special role for H3.3 in tumorigenesis?Chromosoma · 2015Review
- Role of Hox genes in stem cell differentiation.World journal of stem cells · 2015Review
- Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.Molecular cell · 2015Article
- Predicting the human epigenome from DNA motifs.Nature methods · 2015Article
- Comprehensive comparative homeobox gene annotation in human and mouse.Database : the journal of biological databases and curation · 2015Article
- Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.Epigenetics · 2014Article
- Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes.eLife · 2014Article
- Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.Cell reports · 2014Article
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.Nature reviews. Molecular cell biology · 2014Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Polycomb group (PcG)-mediated repression is an evolutionarily conserved process critical for cell fate determination and maintenance of gene expression during embryonic development. However, the mechanisms underlying PcG recruitment in mammals remain unclear since few regulatory sites have been identified. We report two novel prospective PcG-dependent regulatory elements within the human HOXB and HOXC clusters and compare their repressive activities to a previously identified element in the HOXD cluster. These regions recruited the PcG proteins BMI1 and SUZ12 to a reporter construct in mesenchymal stem cells and conferred repression that was dependent upon PcG expression. Furthermore, we examined the potential of two DNA-binding proteins, JARID2 and YY1, to regulate PcG activity at these three elements. JARID2 has differential requirements, whereas YY1 appears to be required for repressive activity at all 3 sites. We conclude that distinct elements of the mammalian HOX clusters can recruit components of the PcG complexes and confer repression, similar to what has been seen in Drosophila. These elements, however, have diverse requirements for binding factors, which, combined with previous data on other loci, speaks to the complexity of PcG targeting in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.