ReviewNature reviews. Genetics2013
Pitfalls of predicting complex traits from SNPs.
Review in Nature reviews. Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 415 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
415 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Overcoming attenuation bias in regressions using polygenic indices.Nature communications · 2023Pooled it
- Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets.Nature communications · 2021Pooled it
- Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.Nature communications · 2020Pooled it
- Metasubtract: an R-package to analytically produce leave-one-out meta-analysis GWAS summary statistics.Bioinformatics (Oxford, England) · 2020Pooled it
- Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes.International journal of molecular sciences · 2020Pooled it
- Polygenic risk for alcohol consumption and multisite chronic pain: Associations with ad lib drinking behavior.Experimental and clinical psychopharmacology · 2023Trial
- Extending genome-wide association studies to admixed cohorts with high degrees of relatedness.Nature genetics · 2026Article
- Interpretable and Predictive Models Based on High-Dimensional Data in Ecology and Evolution.Molecular ecology resources · 2026Article
- An efficient LASSO framework for admixture-aware polygenic scores.HGG advances · 2026Article
- Within-sibling attenuation of polygenic risk score accuracy: investigating the effects of principal component analysis, LD score regression, and mixed model association in the UK Biobank.Human genetics · 2026Article
- Associations among discrimination, genetic susceptibility to inflammation, and C-reactive protein.Brain, behavior, & immunity - health · 2026Article
- Fine-Mapping-Based Variant Prioritization and Genomic Prediction Enhance Genetic Analyses of Teat Traits in Pigs.Animals : an open access journal from MDPI · 2026Article
- Genomic-Relatedness Matching Expands Population Coverage, Improves Power, and Reduces Bias in Genetic Association Analyses.medRxiv : the preprint server for health sciences · 2026Article
- Reply: neutral transcriptome rewiring promotes quantitative disease resistance evolvability at the species level.The Plant cell · 2026Article
- Genetic confounding in the associations between maternal health and autism.medRxiv : the preprint server for health sciences · 2026Article
- A simple approach for multiple observations improves power to detect genetic effects and genomic prediction accuracy.HGG advances · 2026Article
- Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms.Genetics · 2026Article
- A Flexible Method for Genomics-Based Quantitative Genetics in Wild Study Systems-A Case Study on a House Sparrow Meta-Population.Evolutionary applications · 2026Article
- Exploring standing genetic variation for barley leaf rust resistance in Australian breeding panel.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Unveiling the Genomic Architecture of Phenotypic Plasticity Using Multiple GWAS Approaches Under Contrasting Conditions of Water Availability: A Model for Barley.International journal of molecular sciences · 2026Article
355 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The success of genome-wide association studies (GWASs) has led to increasing interest in making predictions of complex trait phenotypes, including disease, from genotype data. Rigorous assessment of the value of predictors is crucial before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how naive implementations can lead to severe bias and misinterpretation of results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.