ArticleEnvironmental health perspectives2013
Lifetime pesticide use and telomere shortening among male pesticide applicators in the Agricultural Health Study.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 75 citations in OpenAlex.
- Co-Exposure with the Herbicide 2,4-D Does Not ExacerbateAnimals : an open access journal from MDPI · 2025Article
- Occupational pesticide use and relative leukocyte telomere length in the biomarkers of exposure and effect in agriculture study.Environmental research · 2025Article
- Association Between Prenatal Exposure to Organochlorine Pesticides and Telomere Length in Neonatal Cord Blood.Toxics · 2024Article
- Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated.Frontiers in public health · 2023Article
- Persistent organic pollutants and risk of cutaneous malignant melanoma among women.Cancer reports (Hoboken, N.J.) · 2022Article
- Exposure to Airborne Pesticides and Its Residue in Blood Serum of Paddy Farmers in Malaysia.International journal of environmental research and public health · 2022Article
- Association between maternal urinary selenium during pregnancy and newborn telomere length: results from a birth cohort study.European journal of clinical nutrition · 2022Article
- Article
- Fish from urban rivers and with high pollutant levels have shorter telomeres.Biology letters · 2021Article
- Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases.La Medicina del lavoro · 2019Article
- Evaluation of Dermal Exposure to the Herbicide Alachlor Among Vegetable Farmers in Thailand.Annals of work exposures and health · 2018Article
- Alachlor Use and Cancer Incidence in the Agricultural Health Study: An Updated Analysis.Journal of the National Cancer Institute · 2018Article
- Beginning at the ends: telomeres and human disease.F1000Research · 2018Review
- Management of suspected monogenic lung fibrosis in a specialised centre.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- The Relationship Between Childhood Psychosocial Stressor Level and Telomere Length: A Meta-Analysis.Health psychology research · 2017Article
- Environmental Chemicals and Aging.Current environmental health reports · 2017Review
- Associations of Buccal Cell Telomere Length with Daily Intake of β-Carotene or α-Tocopherol Are Dependent on Carotenoid Metabolism-related Gene Polymorphisms in Healthy Japanese Adults.The journal of nutrition, health & aging · 2016Article
- Use of acetochlor and cancer incidence in the Agricultural Health Study.International journal of cancer · 2015Article
- Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.Carcinogenesis · 2015Review
- Investing in prospective cohorts for etiologic study of occupational exposures.American journal of industrial medicine · 2015Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundTelomere length (TL) in surrogate tissues may be influenced by environmental exposures.
objectiveWe aimed to determine whether lifetime pesticides use is associated with buccal cell TL.
methodsWe examined buccal cell TL in relation to lifetime use of 48 pesticides for 1,234 cancer-free white male pesticide applicators in the Agricultural Health Study (AHS), a prospective cohort study of 57,310 licensed pesticide applicators. Participants provided detailed information on lifetime use of 50 pesticides at enrollment (1993-1997). Buccal cells were collected from 1999 to 2006. Relative telomere length (RTL) was measured using quantitative real-time polymerase chain reaction. We used linear regression modeling to evaluate the associations between specific pesticides and the logarithm of RTL, adjusting for age at buccal cell collection, state of residence, applicator license type, chewing tobacco use, and total lifetime days of all pesticide use.
resultsThe mean RTL for participants decreased significantly in association with increased lifetime days of pesticide use for alachlor (p = 0.002), 2,4-dichlorophenoxyacetic acid (2,4-D; p = 0.004), metolachlor (p = 0.01), trifluralin (p = 0.05), permethrin (for animal application) (p = 0.02), and toxaphene (p = 0.04). A similar pattern of RTL shortening was observed with the metric lifetime intensity-weighted days of pesticide use. For dichlorodiphenyltrichloroethane (DDT), we observed significant RTL shortening for lifetime intensity-weighted days (p = 0.04), but not for lifetime days of DDT use (p = 0.08). No significant RTL lengthening was observed for any pesticide.
conclusionSeven pesticides previously associated with cancer risk in the epidemiologic literature were inversely associated with RTL in buccal cell DNA among cancer-free pesticide applicators. Replication of these findings is needed because we cannot rule out chance or fully rule out bias.
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