ArticleHypertension (Dallas, Tex. : 1979)2013
Role of Axl in early kidney inflammation and progression of salt-dependent hypertension.
Article in Hypertension (Dallas, Tex. : 1979), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- From pathogenesis to therapeutic targeting: new insight into TAM receptors in rheumatoid arthritis.Cell & bioscience · 2025Review
- Recent progress in exosomal non-coding RNAs research related to idiopathic pulmonary fibrosis.Frontiers in genetics · 2025Review
- Targeting AXL cellular networks in kidney fibrosis.Frontiers in immunology · 2024Article
- Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.Journal of the American Heart Association · 2020Article
- Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains.British journal of pharmacology · 2019Article
- TAM receptors in cardiovascular disease.Cardiovascular research · 2019Review
- AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction.Physiological reports · 2019Article
- Vitamin K Dependent Proteins in Kidney Disease.International journal of molecular sciences · 2019Review
- Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency.Experimental and therapeutic medicine · 2019Article
- Search for New Candidate Genes Involved in the Comorbidity of Asthma and Hypertension Based on Automatic Analysis of Scientific Literature.Journal of integrative bioinformatics · 2018Article
- Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney.The American journal of pathology · 2018Article
- Protective Effects of Pterostilbene Against Myocardial Ischemia/Reperfusion Injury in Rats.Inflammation · 2017Article
- Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Protective Effects of Growth Arrest-Specific Protein 6 (Gas6) on Sepsis-Induced Acute Kidney Injury.Inflammation · 2016Article
- Axl modulates immune activation of smooth muscle cells in vein graft remodeling.American journal of physiology. Heart and circulatory physiology · 2015Article
- Autonomic dysfunction determines stress-induced cardiovascular and immune complications in mice.Journal of the American Heart Association · 2015Article
- Axl as a mediator of cellular growth and survival.Oncotarget · 2014Review
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The Gas6/Axl pathway regulates many cell functions and is implicated in hypertension. In this study, we aimed to investigate the role of Axl in immune cells on initiation and progression of salt-dependent hypertension. Deoxycorticosterone acetate (75 mg/60 days release)-salt hypertension was induced for 1 week or 6 weeks in Axl chimeras generated by bone marrow transplant to restrict Axl deficiency to hematopoietic or nonhematopoietic compartments. Depletion of Axl in hematopoietic cells (Axl(-/-) →Axl(+/+)) reduced (133 ± 2 mm Hg) increase in systolic blood pressure compared with other Axl chimeras (≈150 mm Hg) 1 week after deoxycorticosterone acetate-salt. Urine protein and renal oxidative stress were lowest in Axl(-/-) →Axl(+/+) at 1 week after deoxycorticosterone acetate-salt. Compensatory increase in Gas6 in kidneys of recipient Axl(-/-) may affect kidney function and blood pressure in early phase of hypertension. Flow cytometry on kidneys from Axl(-/-) →Axl(+/+) showed increase in total leukocytes, B, and dendritic cells and decrease in macrophages compared with Axl(+/+) →Axl(+/+). These immune changes were associated with decrease in proinflammatory gene expression, in particular interferon γ. Systolic blood pressure returned to baseline in Axl(-/-) →Axl(+/+) and Axl(-/-) →Axl(-/-) but remained increased in Axl(+/+) →Axl(+/+) and Axl(+/+) →Axl(-/-) chimeras after 6 weeks of deoxycorticosterone acetate-salt. Vascular apoptosis was increased in the global Axl(-/-) chimeras in the late phase of hypertension. In summary, we found that expression of Axl in hematopoietic cells is critical for kidney pathology in early phase of salt-dependent hypertension. However, Axl in both hematopoietic and nonhematopoietic lineages contributes to the late phase of hypertension.
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Registered trials
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