ArticleThe American journal of surgical pathology2013
ERG expression in epithelioid sarcoma: a diagnostic pitfall.
Article in The American journal of surgical pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Angiosarcoma: a systematic review of biomarkers in diagnosis, prognosis, and therapeutic strategies.Frontiers in oncology · 2025Pooled it
- Epithelioid Sarcoma: A Review and Update.Cancers · 2026Review
- Epithelioid Sarcoma of the Oral Cavity: A Multi-institutional Clinicopathologic and Immunophenotypic Characterization of Five Cases and Comprehensive Literature Review.Head and neck pathology · 2026Review
- A mouse model of HPV-associated cervicovaginal carcinosarcoma with comparative analysis to human clinical cases.Cell & bioscience · 2026Article
- Immunoreactivity for CD34, Desmin, Keratins, KIT, Alpha-Smooth Muscle Actin, S100, and Vimentin in Malignant Mesenchymal Neoplasms in Guinea Pigs: A Series of 62 Cases From a Single Institution.Veterinary medicine and science · 2026Article
- Case Report: Primary epithelioid sarcoma of orbit: first case in Asia and literature review.Frontiers in oncology · 2026Article
- Article
- Primary Epithelioid Angiosarcoma of the Submandibular Gland-A Case Report with Histology-Cytology Correlation and Comprehensive Molecular Analysis.Head and neck pathology · 2024Article
- Translational Aspects of Epithelioid Sarcoma: Current Consensus.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Review
- Paranasal sinus angiosarcoma with facial paralysis as a novel manifestation: a case report and literature review.BMC neurology · 2023Review
- The Recent Advances in Molecular Diagnosis of Soft Tissue Tumors.International journal of molecular sciences · 2023Review
- Malignant rhabdoid tumor of the omentum in an adult male: a case report and literature review.Frontiers in oncology · 2023Article
- Article
- Review
- Epithelioid Sarcoma of the External Auditory Canal: An Uncommon Tumor at an Unusual Site and a Brief Overview of the Literature.Head and neck pathology · 2021Review
- Primary thyroid angiosarcoma in a non-endemic region - a rare case.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie · 2020Article
- What is new in epithelioid soft tissue tumors?Virchows Archiv : an international journal of pathology · 2020Review
- Angiosarcoma of the breast, the unknown-a review of the current literature.Translational cancer research · 2019Review
- Primary epithelioid angiosarcoma of the temporal bone with initial presentation of otalgia.Proceedings (Baylor University. Medical Center) · 2018Article
- Malignant mesenchymal neoplasms of the dermis and subcutis mimicking benign lesions: a case-based review.Virchows Archiv : an international journal of pathology · 2017Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
ERG transcription factor is constitutively expressed in endothelial cells. Because benign and malignant vascular endothelia retain the ERG expression, ERG is considered a useful marker for angiosarcomas and related tumors. ERG is also expressed in a subset of prostate carcinomas and Ewing sarcomas due to ERG-involved translocations; therefore, this marker is also of high interest in the study of these malignancies. In this study, we evaluated 109 epithelioid sarcomas for ERG expression, on the basis of an initial observation of an ERG-positive case. We also studied expression of other endothelial antigens in epithelioid sarcoma. ERG was expressed in 38% of epithelioid sarcomas (41/109), usually with a uniform nuclear staining, similar to that seen in angiosarcomas. However, all epithelioid sarcomas were negative for ERG gene rearrangement indicating that ERG expression is not likely related to ERG-involving translocations in epithelioid sarcoma. Other endothelial markers, CD31, claudin 5, and Prox1, were absent in epithelioid sarcomas. The only exception was a pulmonary metastasis of epithelioid sarcoma showing focal CD31 expression, which probably resulted from antigen adsorption onto tumor cell surfaces. However, podoplanin was commonly (7/9) expressed in epithelioid sarcoma; therefore, this marker is not useful in distinguishing epithelioid sarcoma from angiosarcoma. INI1/SMARCB1 gene product was absent in all epithelioid sarcomas (considered here a definitional feature) but was absent from only 1 epithelioid angiosarcoma, indicating its relative specificity for epithelioid sarcoma in this differential diagnostic setting. ERG expression is fairly common in epithelioid sarcoma and should be recognized as a diagnostic pitfall in the differential diagnosis of epithelioid sarcoma and epithelioid angiosarcoma. General lack of endothelial cell-specific markers in epithelioid sarcoma helps in this distinction.
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Registered trials
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