ArticleBMC microbiology2013
Polymyxin P is the active principle in suppressing phytopathogenic Erwinia spp. by the biocontrol rhizobacterium Paenibacillus polymyxa M-1.
Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Protective Rhizobacterial Strains Against Black Shoot Blight Caused by Erwinia pyrifoliae on Apple Plants.The plant pathology journal · 2026Article
- Genomic Insights Into Biocontrol and Plant Growth-Promoting Mechanisms of Paenibacillus maysiensis LHJ6 Against Root Rot in Panax notoginseng.Plant, cell & environment · 2026Article
- The Influence of Biological Measures on Strawberry Plant Growth, Yield, and Fruit Quality.Plants (Basel, Switzerland) · 2026Article
- Genomic insights into the broad-spectrum antifungal activity of a novel Paenibacillus polymyxa strain X-11.BMC microbiology · 2026Article
- Eco-Friendly Biomass Production and Identification of Active Compounds ofMicroorganisms · 2025Article
- Comparative Genomic Analysis ofGenes · 2024Article
- Article
- Abh, AbrB3, and Spo0A play distinct regulatory roles during polymyxin synthesis inMicrobiology spectrum · 2024Article
- Genomic and phenotypic analyses revealFrontiers in microbiology · 2024Article
- Polymyxins: recent advances and challenges.Frontiers in pharmacology · 2024Review
- Dynamics of Bacterial Communities by Apple Tissue: Implications for Apple Health.Journal of microbiology and biotechnology · 2023Article
- Isolation, Characterization and Whole-Genome Analysis ofJournal of microbiology and biotechnology · 2023Article
- Review
- Biocontrol of Soft RotMicroorganisms · 2023Article
- Causes of polymyxin treatment failure and new derivatives to fill the gap.The Journal of antibiotics · 2022Review
- Antibacterial Activity of a Novel Oligosaccharide fromMolecules (Basel, Switzerland) · 2022Article
- Biocontrol properties from phyllospheric bacteria isolated from Solanum lycopersicum and Lactuca sativa and genome mining of antimicrobial gene clusters.BMC genomics · 2022Article
- GeneFrontiers in microbiology · 2022Article
- Polymyxin BFrontiers in cellular and infection microbiology · 2022Article
- Active Metabolites From the EndophyteFrontiers in chemistry · 2022Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNine gene clusters dedicated to nonribosomal synthesis of secondary metabolites with possible antimicrobial action, including polymyxin and fusaricidin, were detected within the whole genome sequence of the plant growth-promoting rhizobacterium (PGPR) Paenibacillus polymyxa M-1. To survey the antimicrobial compounds expressed by M-1 we analyzed the active principle suppressing phytopathogenic Erwinia spp.
resultsP. polymyxa M-1 suppressed the growth of phytopathogenic Erwinia amylovora Ea 273, and E. carotovora, the causative agents of fire blight and soft rot, respectively. By MALDI-TOF mass spectrometry and reversed-phase high-performance liquid chromatography (RP-HPLC), two antibacterial compounds bearing molecular masses of 1190.9 Da and 1176.9 Da were detected as being the two components of polymyxin P, polymyxin P1 and P2, respectively. The active principle acting against the two Erwinia strains was isolated from TLC plates and identified by postsource decay (PSD)-MALDI-TOF mass spectrometry as polymyxin P1 and polymyxin P2. These findings were corroborated by domain structure analysis of the polymyxin (pmx) gene cluster detected in the M-1 chromosome which revealed that corresponding to the chemical structure of polymyxin P, the gene cluster is encoding D-Phe in position 6 and L-Thr in position 7.
conclusionsIdentical morphological changes in the cell wall of the bacterial phytopathogens treated with either crude polymyxin P or culture supernatant of M-1 corroborated that polymyxin P is the main component of the biocontrol effect exerted by strain M-1 against phytopathogenic Erwinia spp.
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